School of Biomedicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.
Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia.
Disabil Rehabil. 2024 Aug;46(17):3802-3826. doi: 10.1080/09638288.2023.2259299. Epub 2023 Oct 13.
Aphasia is an acquired language impairment that commonly results from stroke. Non-invasive brain stimulation (NIBS) might accelerate aphasia recovery trajectories and has seen mounting popularity in recent aphasia rehabilitation research. The present review aimed to: (1) summarise all existing literature on NIBS as a post-stroke aphasia treatment; and (2) provide recommendations for future NIBS-aphasia research.
Databases for published and grey literature were searched using scoping review methodology. 278 journal articles, conference abstracts/posters, and books, and 38 items of grey literature, were included for analysis.
Quantitative analysis revealed that ipsilesional anodal transcranial direct current stimulation and contralesional 1-Hz repetitive transcranial magnetic stimulation were the most widely used forms of NIBS, while qualitative analysis identified four key themes including: the roles of the hemispheres in aphasia recovery and their relationship with NIBS; heterogeneity of individuals but homogeneity of subpopulations; individualisation of stimulation parameters; and much remains under-explored in the NIBS-aphasia literature.
Taken together, these results highlighted systemic challenges across the field such as small sample sizes, inter-individual variability, lack of protocol optimisation/standardisation, and inadequate focus on aphasiology. Four key recommendations are outlined herein to guide future research and refine NIBS methods for post-stroke aphasia treatment.
失语症是一种后天获得性语言障碍，通常由中风引起。非侵入性脑刺激（NIBS）可能会加速失语症恢复轨迹，在最近的失语症康复研究中越来越受到关注。本综述旨在：（1）总结所有关于作为中风后失语症治疗方法的 NIBS 的现有文献；（2）为未来的 NIBS-失语症研究提供建议。
使用范围综述方法搜索已发表和灰色文献数据库。共纳入 278 篇期刊文章、会议摘要/海报和书籍，以及 38 篇灰色文献进行分析。
定量分析显示，同侧阳极经颅直流电刺激和对侧 1Hz 重复经颅磁刺激是最广泛使用的 NIBS 形式，而定性分析确定了四个关键主题，包括：大脑半球在失语症恢复中的作用及其与 NIBS 的关系；个体的异质性但亚群的同质性；刺激参数的个体化；以及 NIBS-失语症文献中仍有许多方面尚未得到充分探索。
综上所述，这些结果强调了该领域存在的系统性挑战，例如样本量小、个体间变异性、缺乏方案优化/标准化以及对失语症的关注不足。本文概述了四项关键建议，以指导未来的研究并完善用于中风后失语症治疗的 NIBS 方法。
