Baig Sheharyar S, Dorney Samantha, Aziz Mudasar, Bell Simon M, Ali Ali N, Su Li, Redgrave Jessica N, Majid Arshad
Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, Sheffield, UK.
Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust, Doncaster, UK.
Neural Regen Res. 2025 Dec 1;20(12):3388-3399. doi: 10.4103/NRR.NRR-D-24-00945. Epub 2024 Dec 7.
Stroke remains a leading cause of long-term disability worldwide. There is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological recovery. Transcutaneous vagus nerve stimulation has been demonstrated to show potential therapeutic effects in both acute and chronic stroke. However, previously published research has only investigated a narrow range of stimulation settings and indications. In this review, we detail the ongoing studies of transcutaneous vagus nerve stimulation in stroke through systematic searches of registered clinical trials. We summarize the upcoming clinical trials of transcutaneous vagus nerve stimulation in stroke, highlighting their indications, parameter settings, scope, and limitations. We further explore the challenges and barriers associated with the implementation of transcutaneous vagus nerve stimulation in acute stroke and stroke rehabilitation, focusing on critical aspects such as stimulation settings, target groups, biomarkers, and integration with rehabilitation interventions.
中风仍然是全球长期残疾的主要原因。对于能够减轻神经血管损伤并可能促进神经功能恢复的神经调节疗法存在未满足的需求。经皮迷走神经刺激已被证明在急性和慢性中风中均显示出潜在的治疗效果。然而，先前发表的研究仅调查了狭窄范围的刺激设置和适应症。在本综述中，我们通过系统检索注册的临床试验详细介绍了经皮迷走神经刺激在中风方面的正在进行的研究。我们总结了即将开展的经皮迷走神经刺激治疗中风的临床试验，突出了它们的适应症、参数设置、范围和局限性。我们进一步探讨了在急性中风和中风康复中实施经皮迷走神经刺激所面临的挑战和障碍，重点关注刺激设置、目标群体、生物标志物以及与康复干预措施整合等关键方面。
