胎生蟑螂基因组揭示了与昆虫及其他生物胎生相关的趋同进化机制。
Live-bearing cockroach genome reveals convergent evolutionary mechanisms linked to viviparity in insects and beyond.
作者信息
Fouks Bertrand, Harrison Mark C, Mikhailova Alina A, Marchal Elisabeth, English Sinead, Carruthers Madeleine, Jennings Emily C, Chiamaka Ezemuoka L, Frigard Ronja A, Pippel Martin, Attardo Geoffrey M, Benoit Joshua B, Bornberg-Bauer Erich, Tobe Stephen S
机构信息
University of Münster, Institute for Evolution and Biodiversity, Molecular Evolution and Bioinformatics, Hüfferstrasse 1, 48149 Münster, Germany.
Department of Biology, Molecular Developmental Physiology and Signal Transduction Lab., Division of Animal Physiology and Neurobiology, Naamsestraat 59-Box 2465, B-3000 Leuven, Belgium.
出版信息
iScience. 2023 Sep 9;26(10):107832. doi: 10.1016/j.isci.2023.107832. eCollection 2023 Oct 20.
Live birth (viviparity) has arisen repeatedly and independently among animals. We sequenced the genome and transcriptome of the viviparous Pacific beetle-mimic cockroach and performed comparative analyses with two other viviparous insect lineages, tsetse flies and aphids, to unravel the basis underlying the transition to viviparity in insects. We identified pathways undergoing adaptive evolution for insects, involved in urogenital remodeling, tracheal system, heart development, and nutrient metabolism. Transcriptomic analysis of cockroach and tsetse flies revealed that uterine remodeling and nutrient production are increased and the immune response is altered during pregnancy, facilitating structural and physiological changes to accommodate and nourish the progeny. These patterns of convergent evolution of viviparity among insects, together with similar adaptive mechanisms identified among vertebrates, highlight that the transition to viviparity requires changes in urogenital remodeling, enhanced tracheal and heart development (corresponding to angiogenesis in vertebrates), altered nutrient metabolism, and shifted immunity in animal systems.
胎生（体内受精并产出幼体）在动物界已多次独立出现。我们对胎生的太平洋拟步甲蟑螂的基因组和转录组进行了测序，并与另外两个胎生昆虫谱系——采采蝇和蚜虫进行了比较分析，以揭示昆虫向胎生转变的潜在基础。我们确定了昆虫中经历适应性进化的途径，这些途径涉及泌尿生殖系统重塑、气管系统、心脏发育和营养代谢。对蟑螂和采采蝇的转录组分析表明，怀孕期间子宫重塑和营养物质产生增加，免疫反应发生改变，从而促进结构和生理变化以容纳和滋养后代。昆虫中胎生的这些趋同进化模式，以及在脊椎动物中发现的类似适应性机制，都突出表明向胎生的转变需要动物系统中泌尿生殖系统重塑的变化、气管和心脏发育的增强（对应于脊椎动物中的血管生成）、营养代谢的改变以及免疫的转变。
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