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利用二硫化钼和离子液体修饰的碳糊电极开发用于检测叶酸的高灵敏度伏安传感器。

Development of a highly sensitive voltammetric sensor for the detection of folic acid by using MoS and ionic liquid-modified carbon paste electrode.

作者信息

Nejad Hadi Soltani, Nejad Fariba Garkani, Beitollahi Hadi

机构信息

Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran.

Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman 7631818356, Iran.

出版信息

ADMET DMPK. 2023 Jul 22;11(3):361-371. doi: 10.5599/admet.1823. eCollection 2023.

DOI:10.5599/admet.1823
PMID:37829321
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10567065/
Abstract

BACKGROUND AND PURPOSE

Sensitive analytical determination of folic acid is important in clinical laboratories due to its versatile biological functions.

EXPERIMENTAL APPROACH

A simple folic acid sensor was successfully fabricated based on two-dimensional transition metal dichalcogenide MoS modified carbon ionic liquid paste electrode (MoS-CILPE). The electrochemical properties of the fabricated electrode were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and chronoamperometry.

KEY RESULTS

The fabricated sensor displayed excellent electroactivity towards folic acid using CV. Under optimal conditions (0.1 M PBS (pH 7.0)), the DPV oxidation peak current was proportional to folic acid concentration in the range from 5.0 μM to 100.0 μM with an estimated limit of detection of 1.0 μM and limit of quantification of 5.0 μM.

CONCLUSION

The ability of the sensor for routine analyses was demonstrated by the detection of folic acid present in folic acid tablets and urine samples with appreciable recovery values.

摘要

背景与目的

由于叶酸具有多种生物学功能，因此在临床实验室中对其进行灵敏的分析测定至关重要。

实验方法

基于二维过渡金属二硫属化物MoS修饰的碳离子液体糊电极（MoS-CILPE）成功制备了一种简单的叶酸传感器。通过循环伏安法（CV）、差分脉冲伏安法（DPV）和计时电流法研究了所制备电极的电化学性质。

主要结果

使用CV时，所制备的传感器对叶酸表现出优异的电活性。在最佳条件（0.1 M PBS（pH 7.0））下，DPV氧化峰电流与叶酸浓度在5.0 μM至100.0 μM范围内成正比，估计检测限为1.0 μM，定量限为5.0 μM。

结论

通过检测叶酸片和尿液样品中存在的叶酸并获得可观的回收率值，证明了该传感器用于常规分析的能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e7/10567065/7fbbdf3b6966/ADMET-11-1823-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e7/10567065/f50b1146cc77/ADMET-11-1823-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e7/10567065/6f9aa19f6eec/ADMET-11-1823-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e7/10567065/06a2c3797089/ADMET-11-1823-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e7/10567065/ed71d65acab9/ADMET-11-1823-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e7/10567065/7fbbdf3b6966/ADMET-11-1823-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e7/10567065/f50b1146cc77/ADMET-11-1823-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e7/10567065/6f9aa19f6eec/ADMET-11-1823-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e7/10567065/06a2c3797089/ADMET-11-1823-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e7/10567065/ed71d65acab9/ADMET-11-1823-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e7/10567065/7fbbdf3b6966/ADMET-11-1823-g005.jpg

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