Department of General Practice, People's Hospital of Jingning She Autonomous County, Jingning, China.
Department of Endocrinology, Affiliated Hospital of Jiujiang University, Jiujiang, China.
Nagoya J Med Sci. 2023 Aug;85(3):465-475. doi: 10.18999/nagjms.85.3.465.
We aimed to explore the correlations of high molecular weight adiponectin (HMW-ADP), tumor necrosis factor-alpha (TNF-α) and vascular endothelial growth factors (VEGFs) with the occurrence of colonic polyps in the prediabetic population. Two hundred patients with prediabetes were enrolled, and their clinical data were retrospectively analyzed. They were divided into group A (75 patients with colonic polyps) and group B (125 patients without colonic polyps). Eighty patients with normal glucose tolerance in the same period were divided into group C (32 patients with normal glucose tolerance and colonic polyps) and group D (48 patients with normal glucose tolerance but no colonic polyps). The correlations of serum HMW-ADP, TNF-α and VEGF levels with plasma glucose and insulin levels were explored by Pearson's analysis. The factors influencing the occurrence of colonic polyps were determined by logistic regression analysis. Serum HMW-ADP was negatively correlated with TNF-α, VEGFs, FPG, 2hPG, FI and HOMA-IR (<0, P<0.05), whereas serum TNF-α and VEGFs were positively correlated with FPG, 2hPG, FI and HOMA-IR (>0, P<0.05). Age, body mass index, waist-to-hip ratio, history of smoking, history of drinking, family history of colon cancer, TNF-α and VEGF were independent risk factors [odds ratio (OR)>1, P<0.05], and HMW-ADP was a protective factor (OR<1, P<0.05). The areas under the curves of serum HMW-ADP, TNF-α, VEGFs and their combination for predicting the occurrence of colonic polyps were 0.899, 0.787, 0.908 and 0.922, respectively. The combination of HMW-ADP, TNF-α and VEGFs can effectively predict the occurrence of colonic polyps in prediabetic patients.
我们旨在探讨高分子量脂联素（HMW-ADP）、肿瘤坏死因子-α（TNF-α）和血管内皮生长因子（VEGFs）与糖尿病前期人群结肠息肉发生的相关性。纳入 200 例糖尿病前期患者，回顾性分析其临床资料。将其分为 A 组（75 例有结肠息肉）和 B 组（125 例无结肠息肉）。同期选取 80 例糖耐量正常者分为 C 组（32 例糖耐量正常伴结肠息肉）和 D 组（48 例糖耐量正常无结肠息肉）。采用 Pearson 分析探讨血清 HMW-ADP、TNF-α 和 VEGF 水平与血浆血糖和胰岛素水平的相关性。采用 logistic 回归分析确定影响结肠息肉发生的因素。血清 HMW-ADP 与 TNF-α、VEGFs、FPG、2hPG、FI 和 HOMA-IR 呈负相关（<0，P<0.05），而血清 TNF-α和 VEGFs 与 FPG、2hPG、FI 和 HOMA-IR 呈正相关（>0，P<0.05）。年龄、体重指数、腰臀比、吸烟史、饮酒史、结肠癌家族史、TNF-α和 VEGF 是独立危险因素[比值比（OR）>1，P<0.05]，HMW-ADP 是保护因素（OR<1，P<0.05）。血清 HMW-ADP、TNF-α、VEGFs 及其联合预测结肠息肉发生的曲线下面积分别为 0.899、0.787、0.908 和 0.922。HMW-ADP、TNF-α 和 VEGFs 的联合检测能有效预测糖尿病前期患者结肠息肉的发生。
