息肉与结肠癌的糖尿病关联。

Diabetes association of polyps and colon cancer.

作者信息

Miłek Tomasz, Forysiński Karol, Myrcha Piotr, Ciostek Piotr

机构信息

I Chair and Clinic of General, Vascular and Oncological Surgery at II Faculty of Medicine, Medical University of Warsaw, Poland.

出版信息

Pol Przegl Chir. 2019 Jun 28;91(4):9-12. doi: 10.5604/01.3001.0013.2588.

DOI:10.5604/01.3001.0013.2588

PMID:31481646

Abstract

AIM

The aim of the study was to retrospectively assess the relationship between the occurrence of polyps and colon cancer in patients with type 2 diabetes.

METHODS

In 2014-2015, 976 colonoscopies were performed in patients. We compared the number of polyps with high-grade dysplasia and colorectal cancers in patients with and without diabetes. In addition, in the diabetic group we documented the relationship between HbA1C and the occurrence of polyps with high-grade dysplasia, and colon cancer. The data were statistically analyzed.

RESULTS

Patients with diabetes show a higher incidence of polyps with high-grade dysplasia/carcinoma - 32/91 (35.16%) in comparison to patients without diabetes - 136/885 (15.37%), P < 0.001; 2. Patients with diabetes show a higher incience of polyps with cancer - 9/91 (9.89%) as compared to patients without diabetes - 18/885 (2.03%), P < 0.001. 3) Colorectal cancer occurred significantly more often in uncontrolled diabetes (P = 0.022).

CONCLUSION

The conducted study shows a significant association between type 2 diabetes and the incidence of colorectal adenomas. These findings may lead to a conclusion that diabetic patients are at a higher risk of developing colorectal cancer, thus are in higher need for controlled colonoscopy. Therefore, it may be worth considering a scheme for screening patients in the above-mentioned group with colonoscopy.

摘要

目的

本研究旨在回顾性评估2型糖尿病患者息肉与结肠癌发生之间的关系。

方法

2014年至2015年期间，对患者进行了976次结肠镜检查。我们比较了糖尿病患者和非糖尿病患者中高级别异型增生息肉及结直肠癌的数量。此外，在糖尿病组中，我们记录了糖化血红蛋白（HbA1C）与高级别异型增生息肉及结肠癌发生之间的关系。对数据进行了统计分析。

结果

糖尿病患者高级别异型增生息肉/癌的发生率更高——32/91（35.16%），相比之下非糖尿病患者为136/885（15.37%），P<0.001；2. 糖尿病患者患癌息肉的发生率更高——9/91（9.89%），而非糖尿病患者为18/885（2.03%），P<0.001。3）未控制的糖尿病患者结直肠癌的发生频率显著更高（P = 0.022）。