孢子硫醚：来自真菌的失活柠檬酸烷基酯
Sporothioethers: deactivated alkyl citrates from the fungus .
作者信息
Heinemann Henrike, Becker Kevin, Schrey Hedda, Zeng Haoxuan, Stadler Marc, Cox Russell J
机构信息
OCI, BMWZ, Leibniz University of Hannover Schneiderberg 38 30167 Hannover Germany
Department Microbial Drugs, Helmholtz Centre for Infection Research (HZI) Inhoffenstraße 7 38124 Braunschweig Germany.
出版信息
RSC Adv. 2023 Oct 11;13(42):29768-29772. doi: 10.1039/d3ra06542a. eCollection 2023 Oct 4.
Submerged cultivation of MUCL 54604 resulted in formation of a stereoisomeric mixture of new sulfur-containing sporothriolide derivatives named sporothioethers A and B. The presence of the 2-hydroxy-3-mercaptopropanoic acid moiety attenuates the antimicrobial activity in comparison to the precursor sporothriolide suggesting a detoxification mechanism. However, moderate effects on biofilms of and were observed for sporothriolide and sporothioethers A and B at concentrations below their MICs.
MUCL 54604的深层培养产生了名为孢子硫醚A和B的新型含硫孢子内酯衍生物的立体异构体混合物。与前体孢子内酯相比，2-羟基-3-巯基丙酸部分的存在减弱了抗菌活性，这表明存在一种解毒机制。然而，在低于其最低抑菌浓度（MIC）的浓度下，观察到孢子内酯以及孢子硫醚A和B对生物膜有中等程度的影响。
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