以全血细胞减少为表现的缺铁性贫血：一项来自印度的研究。
Iron Deficiency Anemia Presenting With Pancytopenia: A Study From India.
作者信息
Meena Mahadev, Khichar Satyendra, Pawar Akash, Midha Naresh, Kumar Saurabh, Purohit Abhishek, Bohra Gopal K, Garg Mahendra Kumar, Singhai Abhishek
机构信息
General Medicine, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
General Medicine, All India Institute of Medical Sciences, Jodhpur, Jodhpur, IND.
出版信息
Cureus. 2023 Sep 11;15(9):e45034. doi: 10.7759/cureus.45034. eCollection 2023 Sep.
INTRODUCTION
Iron deficiency anemia (IDA) is the most common cause of anemia worldwide. IDA is commonly associated with thrombocytosis and normal or slightly decreased leukocyte count. Sometimes it can present with thrombocytopenia, but rarely present with pancytopenia. Here we are presenting six cases of severe iron deficiency presenting with pancytopenia, which responded to iron replenishment.
METHODS
This 12-month observational study was conducted in the Department of General Medicine at a tertiary care Centre in India. All cases of pancytopenia (after exclusion of other causes) with IDA were included. IDA was established with the help of a complete blood count (CBC), peripheral smear examination, serum iron studies, and serum ferritin. Results: In our study, CBC at four weeks later of iron transfusion without other supplementation showed significant improvement in hematological parameters.
CONCLUSION
Severe iron deficiency is a reversible etiology of pancytopenia. It should be kept as a differential diagnosis of pancytopenia if common causes of pancytopenia are ruled out.
引言
缺铁性贫血（IDA）是全球范围内贫血最常见的病因。IDA通常与血小板增多症以及白细胞计数正常或略有降低相关。有时它可表现为血小板减少，但很少表现为全血细胞减少。在此，我们报告6例严重缺铁伴全血细胞减少的病例，这些病例对铁剂补充治疗有反应。
方法
这项为期12个月的观察性研究在印度一家三级医疗中心的普通内科进行。纳入所有（排除其他病因后）伴有IDA的全血细胞减少病例。借助全血细胞计数（CBC）、外周血涂片检查、血清铁研究和血清铁蛋白来确诊IDA。结果：在我们的研究中，未进行其他补充治疗仅输血补铁四周后的CBC显示血液学参数有显著改善。
结论
严重缺铁是全血细胞减少的一种可逆转病因。如果排除了全血细胞减少的常见病因，应将其作为全血细胞减少的鉴别诊断之一。
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