Kagzi Yusuf, Money David Bradley, Oxner Asa Zoe, Kagzi Alifiya
MGM Medical College, Indore, India.
University of South Florida, Tampa, FL, USA.
Crit Rev Immunol. 2023;43(4):11-13. doi: 10.1615/CritRevImmunol.2023050290.
Angioedema is a condition characterized by swelling of the skin or mucosa resulting from loss of vascular integrity that leads to swelling of mucosal tissues and can lead to life-threatening respiratory compromise. Drug-induced angioedema is not a frequent side effect seen with angiotensin receptor blockers (ARBs), particularly when there are no other contributing risk factors like a prior episode. Few studies reported subsequent angioedema episodes after ARB use in patients who had a prior episode with angiotensin converting enzyme inhibitors; however, there are very few cases that documented non-fatal angioedema after ARB as the only therapy. We report a rare case of life-threatening anaphylaxis after losartan use. We hope that our case will bring awareness to this rare but fatal side effect in order to quickly recognize it and encourage further research.
血管性水肿是一种以皮肤或黏膜肿胀为特征的病症，其由血管完整性丧失引起，导致黏膜组织肿胀，并可能导致危及生命的呼吸功能不全。药物性血管性水肿并非血管紧张素受体阻滞剂（ARB）常见的副作用，尤其是在没有其他如既往发作史等促成风险因素的情况下。很少有研究报道在既往有血管紧张素转换酶抑制剂发作史的患者中使用ARB后出现后续血管性水肿发作；然而，仅有极少数病例记录了ARB作为唯一治疗药物后发生的非致命性血管性水肿。我们报告了一例使用氯沙坦后发生危及生命的过敏反应的罕见病例。我们希望我们的病例能引起人们对这种罕见但致命的副作用的关注，以便能迅速识别它并鼓励进一步研究。
