Mayo Clinic Health System, Menomonie, WI, USA.
University of Minnesota Medical School, Minneapolis, MN, USA.
J Prim Care Community Health. 2023 Jan-Dec;14:21501319231213744. doi: 10.1177/21501319231213744.
The following describes a case of isolated visceral angioedema related to an angiotensin II receptor blocker (ARB) medication. Additionally, we discuss the pathophysiology of drug-induced angioedema, various presentations that can be encountered, and the leading theorized mechanisms of how renin-angiotensin-aldosterone system (RAAS) blocking medications lead to angioedema. The goal of sharing this case is to help increase awareness of the possibility of ARB-induced angioedema and to recommend keeping visceral angioedema as part of the differential diagnosis when presented with a patient who is taking an angiotensin converting enzyme inhibitor (ACEI) or ARB medication that is experiencing gastrointestinal symptoms of unclear etiology.
以下描述了一例与血管紧张素 II 受体阻滞剂（ARB）药物相关的孤立性内脏血管性水肿病例。此外，我们还讨论了药物引起的血管性水肿的病理生理学、可能遇到的各种表现，以及肾素-血管紧张素-醛固酮系统（RAAS）阻断药物引起血管性水肿的理论机制。分享这个病例的目的是帮助提高对 ARB 引起的血管性水肿的可能性的认识，并建议在遇到正在服用血管紧张素转换酶抑制剂（ACEI）或 ARB 药物且出现不明原因胃肠道症状的患者时，将内脏血管性水肿作为鉴别诊断的一部分。
