Castillo Rangel Carlos, Marin Gerardo, Diaz Chiguer Dylan Lucia, Villegas López Francisco Alberto, Ramírez-Rodríguez Rodrigo, Gómez Ibarra Alejandro, Aguilar-Velazquez Rosalba, Soto Abraham Julian Eduardo
Department of Neurosurgery, "Hospital Regional 1° de Octubre", Institute of Social Security and Services for State Workers (ISSSTE), Mexico City 07300, Mexico.
Neural Dynamics and Modulation Lab, Cleveland Clinic, Cleveland, OH 44195, USA.
Healthcare (Basel). 2023 Sep 22;11(19):2607. doi: 10.3390/healthcare11192607.
Incoercible or intractable pain is defined as pain that is refractory to pharmacological treatment to such an extent that opioid and analgesic adverse effects outweigh the therapeutic effects. The anterior cingulate cortex (ACC) is involved in the perception of pain, especially emotional pain, so it is logical that cingulotomy has an effective therapeutic effect. Therefore, we evaluated the effectiveness of cingulotomy for the treatment of incoercible pain. An observational, longitudinal, retrospective, and analytical study was carried out on a series of cases in which bilateral cingulotomy was performed for incoercible pain, and follow-up was performed 6 months after neurosurgery in the outpatient clinic at the Neurotraumatology Clinic. A positive correlation was observed between pain intensity and medication use, indicating that an increase in pain was associated with a greater requirement for analgesics. The result was a significant reduction in pain, as measured by the visual analog scale of pain, and decreased drug use after cingulotomy. We concluded that cingulotomy reduces incoercible pain and the need for medication.
顽固性或难治性疼痛被定义为对药物治疗无效的疼痛,以至于阿片类药物和镇痛药物的不良反应超过了治疗效果。前扣带回皮质(ACC)参与疼痛的感知,尤其是情感性疼痛,因此扣带回切开术具有有效的治疗效果是合乎逻辑的。因此,我们评估了扣带回切开术治疗顽固性疼痛的有效性。对一系列因顽固性疼痛而进行双侧扣带回切开术的病例进行了一项观察性、纵向、回顾性和分析性研究,并在神经创伤诊所的门诊对神经外科手术后6个月进行了随访。观察到疼痛强度与药物使用之间存在正相关,表明疼痛加剧与镇痛药物需求增加有关。结果是,通过疼痛视觉模拟量表测量,扣带回切开术后疼痛显著减轻,药物使用减少。我们得出结论,扣带回切开术可减轻顽固性疼痛并减少药物需求。