Curtin School of Allied Health, Curtin University, Perth, Western Australia, Australia.
Advanced Heart Failure and Cardiac Transplant Service, Fiona Stanley Hospital, Perth, Western Australia, Australia.
Am J Physiol Heart Circ Physiol. 2023 Dec 1;325(6):H1386-H1393. doi: 10.1152/ajpheart.00468.2023. Epub 2023 Oct 13.
Impaired endothelial function in people with coronary heart disease (CHD) is associated with increased mortality. Water immersion can increase peripheral artery shear stress which may provide an additional stimulus to the endothelium during exercise. This study compared the effects of water-based circuit exercise training (WEX) and gym-based circuit exercise training (GEX) on vascular function in people with stable CHD. Participants were randomized to 12 wk of WEX ( = 20), GEX ( = 20), or a control group (usual activities; = 12). Endothelium-dependent flow-mediated dilation (FMD) and glyceryl trinitrate-mediated dilation (GTN) of the brachial artery were assessed pre- and postintervention. FMD increased following WEX [4.0% (3.0%-5.1%) to 5.3% (4.1%-6.5%); = 0.016], but was unchanged following GEX [4.9% (3.8%-5.9%) to 5.0% (3.8%-6.1%); = 0.822]. There were no between-group differences in the change in FMD and no significant changes in GTN-mediated dilation percentage. Triglycerides decreased following GEX [1.2 mmol·L (1.0-1.4 mmol·L) to 1.0 mmol·L (0.8-1.3 mmol·L); = 0.022], but there were no further differences in lipid profiles. WEX improved endothelial function of the brachial artery in people with stable CHD, suggesting that WEX is an effective alternative to gym-based exercise in people living with CHD, which may specifically address vascular health. This study found that 12 wk of water-based circuit exercise training was well tolerated and improved vascular endothelial function in people with stable coronary heart disease. However, there was no effect on endothelium-independent function. Water-based exercise appears to be an effective alternative to gym-based exercise for people with coronary heart disease, which has specific benefits to vascular health and function.
患有冠心病 (CHD) 的人群，其内皮功能受损与死亡率增加相关。水浸可增加外周动脉剪切力，这可能在运动过程中为内皮提供额外刺激。本研究比较了水基循环运动训练 (WEX) 和健身房基循环运动训练 (GEX) 对稳定型 CHD 患者血管功能的影响。参与者被随机分配到 12 周的 WEX（n=20）、GEX（n=20）或对照组（常规活动；n=12）。在干预前后评估肱动脉内皮依赖性血流介导的扩张 (FMD) 和硝化甘油介导的扩张 (GTN)。WEX 后 FMD 增加[4.0%（3.0%-5.1%）增加至 5.3%（4.1%-6.5%）；=0.016]，而 GEX 后 FMD 无变化[4.9%（3.8%-5.9%）增加至 5.0%（3.8%-6.1%）；=0.822]。FMD 变化无组间差异，GTN 介导的扩张百分比也无显著变化。GEX 后甘油三酯降低[1.2 mmol·L（1.0-1.4 mmol·L）降低至 1.0 mmol·L（0.8-1.3 mmol·L）；=0.022]，但血脂谱无进一步差异。WEX 改善了稳定型 CHD 患者肱动脉的内皮功能，表明 WEX 是 CHD 患者进行健身房运动的有效替代方法，可能专门针对血管健康。本研究发现，12 周的水基循环运动训练耐受良好，可改善稳定型冠心病患者的血管内皮功能。然而，对非内皮依赖性功能没有影响。水基运动似乎是 CHD 患者进行健身房运动的有效替代方法，对血管健康和功能具有特定益处。
