Department of Rheumatology, The Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150000, China.
Department of Rheumatology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150000, China.
Inflammopharmacology. 2023 Dec;31(6):2995-3004. doi: 10.1007/s10787-023-01343-5. Epub 2023 Oct 13.
Rheumatoid arthritis (RA) is typified by persistent joint inflammation, which leads to the deterioration of bone and cartilage and a reduction in overall quality of life. The global prevalence of pain as a primary symptom in RA is influenced by the interplay between inflammation and its resolution. The identification of a family of lipid mediators known as specialized pro-resolving mediators (SPM)s has contributed to the progress of our comprehension of inflammatory conditions. SPMs have been observed to trigger the process of inflammation resolution, thereby reinstating the homeostasis of the inflammatory response. Autacoids are synthesized through the stereo-selective transformation of essential fatty acids, resulting in molecules dynamically modulated during inflammation and possessing strong immunoregulatory properties. This review delves into the available evidence that supports the involvement of certain SPM as protective lipids, biomarkers with potential, and therapeutic targets in the context of RA.
类风湿关节炎（RA）的特征是持续的关节炎症，这导致骨和软骨的恶化以及整体生活质量的下降。全球范围内，RA 以疼痛为主要症状的患病率受到炎症及其消退之间相互作用的影响。一类被称为特异性促解决介质（SPM）的脂质介质的发现，促进了我们对炎症状态的理解。已经观察到 SPM 触发炎症消退过程，从而恢复炎症反应的体内平衡。自体活性物质是通过必需脂肪酸的立体选择性转化合成的，导致在炎症过程中动态调节的分子，并具有强大的免疫调节特性。这篇综述深入探讨了现有的证据，这些证据支持某些 SPM 作为保护性脂质、有潜力的生物标志物和治疗靶点在 RA 中的作用。
