二十二碳六烯酸衍生的促解决脂质介质的潜在临床应用
Potential Clinical Applications of Pro-Resolving Lipids Mediators from Docosahexaenoic Acid.
机构信息
Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380000, Chile.
Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 7810000, Chile.
出版信息
Nutrients. 2023 Jul 26;15(15):3317. doi: 10.3390/nu15153317.
Docosahexaenoic acid (C22:6-3, DHA) is the precursor of specialized pro-resolving lipid mediators (SPMs), such as resolvin, protectin, and maresin families which have been considered therapeutic bioactive compounds for human health. Growing evidence indicates that DHA and SPMs are beneficial strategies in the amelioration, regulation, and duration of inflammatory processes through different biological actions. The present review discusses the reported therapeutic benefits of SPMs on various diseases and their potential clinical applications.
二十二碳六烯酸（C22:6-3，DHA）是特殊的促解决脂质介质（SPM）的前体，如 resolvin、protectin 和maresin 家族，它们被认为是人类健康的治疗性生物活性化合物。越来越多的证据表明，DHA 和 SPM 通过不同的生物学作用，是改善、调节和延长炎症过程的有益策略。本综述讨论了 SPM 在各种疾病中的治疗益处及其潜在的临床应用。
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