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Neuropeptide Y enhances the inhibitory effects of clonidine on 3H-noradrenaline release in synaptosomes isolated from the medulla oblongata of the male rat.

作者信息

Martire M, Fuxe K, Pistritto G, Preziosi P, Agnati L F

出版信息

J Neural Transm. 1986;67(1-2):113-24. doi: 10.1007/BF01243364.

DOI:10.1007/BF01243364
PMID:3783148
Abstract

In studies on superfused synaptosomes from the rat medulla oblongata, the inhibitory effects of the alpha 2-adrenergic agonist clonidine (0.1 microM) on potassium (15 mM K+) induced 3H-noradrenaline (NA) release was potentiated by 20%, when neuropeptide Y was added to the system. The effect of NPY was detectable at low concentrations (1 nM) and was not dose-dependent. Neuropeptide Y alone produced no significant effects on 3H-NA release. The results may indicate the existence of a presynaptic NPY receptor on the noradrenaline and/or adrenaline nerve terminals, which may enhance the presynaptic alpha 2-adrenoreceptor function to inhibit 3H-NA release.

摘要

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2
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Neuropeptide Y increases the inhibitory effects of clonidine on potassium evoked 3H-noradrenaline but not 3H-5-hydroxytryptamine release from synaptosomes of the hypothalamus and the frontoparietal cortex of the male Sprague-Dawley rat.

本文引用的文献

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The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.从大脑中分离神经末梢：对通过匀浆和离心获得的细胞碎片进行的电子显微镜研究。
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Neuropeptide Y: complete amino acid sequence of the brain peptide.神经肽Y：脑肽的完整氨基酸序列。
J Neural Transm Gen Sect. 1989;78(1):61-72. doi: 10.1007/BF01247114.
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Reduced inhibitory effects of clonidine and neuropeptide Y on 3H-noradrenaline release from synaptosomes of the medulla oblongata of the spontaneously hypertensive rat.
J Neural Transm. 1989;76(3):181-9. doi: 10.1007/BF01260503.
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Reciprocal interactions between alpha 2-adrenoceptor agonist and neuropeptide Y binding sites in the nucleus tractus solitarius of the rat. A biochemic and autoradiographic analysis.大鼠孤束核中α2-肾上腺素能受体激动剂与神经肽Y结合位点之间的相互作用。生物化学与放射自显影分析。
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Proc Natl Acad Sci U S A. 1982 Sep;79(18):5485-9. doi: 10.1073/pnas.79.18.5485.
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Neuropeptide Y--a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide.神经肽Y——一种与肽YY和胰多肽结构相似的新型脑肽。
Nature. 1982 Apr 15;296(5858):659-60. doi: 10.1038/296659a0.
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Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function.外周去甲肾上腺素能神经元中的神经肽Y（NPY）样免疫反应性及NPY对交感神经功能的影响。
Acta Physiol Scand. 1982 Dec;116(4):477-80. doi: 10.1111/j.1748-1716.1982.tb07171.x.
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Actions of centrally administered neuropeptide Y on EEG activity in different rat strains and in different phases of their circadian cycle.中枢给予神经肽Y对不同大鼠品系及其昼夜节律周期不同阶段脑电图活动的影响。
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Neuropeptide tyrosine (NPY) immunoreactivity in norepinephrine-containing cells and nerves of the mammalian adrenal gland.哺乳动物肾上腺中含去甲肾上腺素的细胞和神经中的神经肽Y免疫反应性
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Neuropeptide Y in vitro selectivity increases the number of alpha 2-adrenergic binding sites in membranes of the medulla oblongata of the rat.神经肽Y的体外选择性增加了大鼠延髓膜中α2-肾上腺素能结合位点的数量。
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Modulation by cholecystokinins of 3H-spiroperidol binding in rat striatum: evidence for increased affinity and reduction in the number of binding sites.
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Presynaptic regulation of the release of catecholamines.儿茶酚胺释放的突触前调节。
Pharmacol Rev. 1980 Dec;32(4):337-62.