Soares Guilherme Augusto, Rodrigues Gustavo Serafim, Buranello Lais Pereira, de Oliveira Ricardo Brandt, de Arruda Miranda José Ricardo
Department of Biophysics and Pharmacology, Biosciences Institute of Botucatu, São Paulo State University, Botucatu 18618-689, São Paulo, Brazil.
Department of Clinical Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto 18618-689, São Paulo, Brazil.
J Pharm Pharmacol. 2023 Dec 8;75(12):1560-1568. doi: 10.1093/jpp/rgad088.
This study aimed to evaluate the effects of prucalopride, a prokinetic agent that acts as a potent serotonin agonist of 5-HT4 receptors, on gastric emptying and small bowel transit and assess its impact on the absorption of metronidazole.
Six healthy volunteers, three men and three women, aged between 20 and 27 years, with a body weight ranging from 50 to 80 kg, were enrolled in this study. The pharmacokinetics and gastrointestinal transit parameters were evaluated simultaneously through pharmacomagnetography assessment, combining alternating current biosusceptometry and blood analysis.
The results showed that prucalopride enhances gastric emptying and small bowel transit when administered orally and significantly impacts the rate of metronidazole absorption, leading to enhanced bioavailability and rapid therapeutic response.
Pharmacomagnetography assessment allows simultaneous tracking of transit by images and is a valuable method for analysing drug absorption using multiple instruments.
本研究旨在评估普芦卡必利（一种作为强效5-HT4受体血清素激动剂的促动力药物）对胃排空和小肠转运的影响，并评估其对甲硝唑吸收的影响。
本研究纳入了6名健康志愿者，3名男性和3名女性，年龄在20至27岁之间，体重在50至80公斤之间。通过药物磁图评估，结合交流电生物电阻抗分析和血液分析，同时评估药代动力学和胃肠道转运参数。
结果表明，口服普芦卡必利可增强胃排空和小肠转运，并显著影响甲硝唑的吸收速率，从而提高生物利用度并产生快速治疗反应。
药物磁图评估可通过图像同时追踪转运情况，是一种使用多种仪器分析药物吸收的有价值方法。
