Rodrigues Gustavo Serafim, Barboza João Miguel, Buranello Laís Pereira, Brandão Vitor Melo, Ferrari Priscileila Colerato, Soares Guilherme Augusto, Miranda José Ricardo de Arruda
Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu 18618-689, São Paulo, Brazil.
Department of Pharmaceutical Sciences, Ponta Grossa State University, Ponta Grossa 84030-900, Paraná, Brazil.
Pharmaceutics. 2024 Mar 2;16(3):351. doi: 10.3390/pharmaceutics16030351.
Floating controlled systems seek to extend the gastric retention time (GRT) of solid pharmaceutical forms by sustaining buoyancy in the stomach without affecting gastric emptying rates. This investigation aimed to evaluate a magnetic floating drug delivery system (MFDDS) under diverse physiological conditions (pressure and viscosity) using an Alternating Current Biosusceptometry (ACB) system by conducting assessments in vitro and in vivo. For in vitro experiments, MFDDSs were placed under different pressures (760, 910, and 1060 mmHg) and viscosities (1, 50, 120, and 320 mPa·s) for evaluation of floating lag time (FLT). For in vivo experiments, eight healthy volunteers participated in two phases (fasting and fed) for gastric parameters (GRT, FLT, and OCTT-orocaecal transit time) assessment, employing the ACB system. The results indicated that pressure, viscosity, and FLT were directly proportional in the in vitro assay; in addition, increases in the OCTT (fasting = 241.9 ± 18.7; fed = 300 ± 46.4), GRT (fasting = 139.4 ± 25.3; fed = 190.2 ± 47.7), and FLT (fasting = 73.1 ± 16.9; fed = 107.5 ± 29.8) were detected in vivo. Our study emphasizes that the ACB system is a valuable technique, and it is capable of tracking and imaging MFDDS in in vitro and in vivo experiments.
漂浮控制系统旨在通过在胃中维持浮力来延长固体药物剂型的胃滞留时间（GRT），而不影响胃排空率。本研究旨在通过交流生物磁测量法（ACB）系统，在体外和体内不同生理条件（压力和粘度）下评估磁性漂浮药物递送系统（MFDDS）。对于体外实验，将MFDDS置于不同压力（760、910和1060 mmHg）和粘度（1、50、120和320 mPa·s）下，以评估漂浮滞后时间（FLT）。对于体内实验，八名健康志愿者参与了两个阶段（空腹和进食），采用ACB系统评估胃参数（GRT、FLT和口盲传输时间-OCTT）。结果表明，在体外试验中，压力、粘度和FLT成正比；此外，在体内检测到口盲传输时间（空腹=241.9±18.7；进食=300±46.4）、胃滞留时间（空腹=139.4±25.3；进食=190.2±47.7）和漂浮滞后时间（空腹=73.1±16.9；进食=107.5±29.8）增加。我们的研究强调，ACB系统是一种有价值的技术，它能够在体外和体内实验中跟踪和成像MFDDS。
