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胆道重建中的短肢:胆道闭锁儿童活体肝移植的回顾性研究。

Short limb in biliary tract reconstruction: A retrospective study of living donor liver transplantation in children with biliary atresia.

机构信息

Liver Transplantation Section, Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Xicheng District, Beijing, PR China.

Department of General Surgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, PR China.

出版信息

Medicine (Baltimore). 2023 Oct 13;102(41):e35396. doi: 10.1097/MD.0000000000035396.

Abstract

Roux-en-Y cholangiojejunostomy is a standard procedure for biliary reconstruction in pediatric living donor liver transplantation (LDLT). However, there is uncertainty on whether the adult standard of Roux branch limb is suitable for pediatric LDLT and its impact on postoperative biliary complications (BC). This study aimed to explore the effect of the short Roux limb and standard limb on pediatric LDLT biliary reconstruction. According to the length of the Roux limb, 168 LDLT children were divided into the routine limb group (n = 108) and the short limb group (n = 60). The incidences of postoperative biliary tract complications between the 2 groups were compared retrospectively. The mean Roux limb length in the short limb group was significantly shorter than that in the routine limb group group (P < .01). There were significant differences in age, height, and weight between the 2 groups (P < .01). However, there were no significant differences in graft-to-recipient weight ratio, intraoperative blood loss, cold ischemia time, and operation time between the 2 groups (P > .01). Moreover, postoperative BC, including refluxing cholangitis, were similar between the 2 groups (P = .876). Furthermore, the history of Kasai surgery, the history of postoperative RC of Kasai, and whether or not the Roux limb was reconstructed had no significant effect on the occurrence of postoperative RC. There was no significant difference in postoperative BC between the short limb and the routine limb in children with living donor liver transplantation.

摘要

Roux-en-Y 胆肠吻合术是小儿活体肝移植(LDLT)中胆道重建的标准术式。然而,对于成人标准的 Roux 分支支是否适用于小儿 LDLT 以及其对术后胆道并发症(BC)的影响尚存在不确定性。本研究旨在探讨短 Roux 支与标准支在小儿 LDLT 胆道重建中的作用。根据 Roux 支的长度,将 168 例 LDLT 患儿分为常规支组(n = 108)和短支组(n = 60)。回顾性比较两组术后胆道并发症的发生率。短支组的平均 Roux 支长度明显短于常规支组(P <.01)。两组在年龄、身高和体重方面存在显著差异(P <.01)。然而,两组在供肝与受体体重比、术中出血量、冷缺血时间和手术时间方面无显著差异(P >.01)。此外,两组术后 BC,包括反流性胆管炎,无显著差异(P =.876)。此外,Kasai 手术史、Kasai 术后 RC 史以及 Roux 支是否重建对术后 RC 的发生无显著影响。对于活体肝移植患儿,短支与常规支在术后 BC 方面无显著差异。

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