National Institute of Mental Health, Klecany, Czech Republic; Third Faculty of Medicine, Charles University, Prague, Czech Republic.
National Institute of Mental Health, Klecany, Czech Republic; MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Psychiatry Res Neuroimaging. 2023 Oct;335:111721. doi: 10.1016/j.pscychresns.2023.111721. Epub 2023 Sep 28.
In this study, we utilized proton magnetic resonance spectroscopy (MRS) to understand the role of glutamate (Glu), glutamine (Gln), and gamma-aminobutyric acid (GABA) of OCD patients in the pregenual anterior cingulate cortex (pgACC). In total, 54 patients with OCD and 54 healthy controls (HC) matched for age and sex were included in the study. They underwent MRS in the pgACC region to calculate the concentrations of Glu, Gln, GABA, and Glu + Gln (Glx). After quality control of the MRS data, 21 OCD and 21 HC were statistically analyzed. The severity of symptoms were evaluated using the Yale-Brown Obsessive-Compulsive Scale (YBOCS). In the statistical analysis, we compared differences between groups for the metabolites; in the OCD we analyzed the correlations with symptom severity, medication status, age, and duration of illness. A significant decrease in Glx, in Glu, and in Gln in the pgACC were observed in the OCD compared to HC. The correlation statistics showed a significant positive correlation between Glu levels and the YBOCS compulsions subscale. The results indicate that patients with OCD present a disturbance in glutamatergic metabolism in the pgACC. The results also demonstrate that these changes correlate with the severity of compulsions.
在这项研究中，我们利用质子磁共振波谱（MRS）来了解强迫症（OCD）患者前扣带回皮质前嘴部（pgACC）中谷氨酸（Glu）、谷氨酰胺（Gln）和γ-氨基丁酸（GABA）的作用。共有 54 名 OCD 患者和 54 名年龄和性别匹配的健康对照（HC）纳入研究。他们在 pgACC 区域接受 MRS 以计算 Glu、Gln、GABA 和 Glu+Gln（Glx）的浓度。对 MRS 数据进行质量控制后，对 21 名 OCD 和 21 名 HC 进行了统计学分析。使用耶鲁-布朗强迫症量表（YBOCS）评估症状严重程度。在统计分析中，我们比较了两组代谢物之间的差异；在 OCD 中，我们分析了与症状严重程度、药物状况、年龄和病程的相关性。与 HC 相比，OCD 患者 pgACC 中的 Glx、Glu 和 Gln 明显减少。相关性统计显示，Glu 水平与 YBOCS 强迫分表呈显著正相关。结果表明，OCD 患者 pgACC 中存在谷氨酸能代谢紊乱。结果还表明，这些变化与强迫症状的严重程度相关。
