Datz F L, Thorne D A
J Nucl Med. 1986 Dec;27(12):1849-53.
Although 111In-labeled leukocytes have been shown to be a useful technique for detecting infection, it has been postulated that antibiotic therapy may reduce the sensitivity of the leukocyte scan. Many patients with suspected bacterial infections are placed on antibiotics before a definite site of infection has been identified. Three hundred twelve leukocyte scans on 271 patients were retrospectively reviewed and classified as positive or negative, and as to whether or not they were being treated with antibiotics at the time the leukocyte scan was performed. The overall sensitivity, considering all 312 studies, was 90%. One hundred sixty-nine patient studies were on patients receiving antibiotics; 143 studies were on patients not on antibiotics. The sensitivity of the leukocyte scan was 88.7% in patients on antibiotic therapy; it was 92.1% in those who were not receiving antibiotics. The differences in sensitivity between the two groups were not significantly different (p less than 0.05). We conclude that antibiotic therapy does not affect the sensitivity of the 111In-labeled leukocyte scan.
尽管已证明铟 - 111标记的白细胞是检测感染的一种有用技术，但据推测抗生素治疗可能会降低白细胞扫描的敏感性。许多疑似细菌感染的患者在确定感染的确切部位之前就开始使用抗生素。对271例患者的312次白细胞扫描进行了回顾性分析，并将其分为阳性或阴性，同时记录白细胞扫描时患者是否正在接受抗生素治疗。考虑到所有312项研究，总体敏感性为90%。其中169例患者正在接受抗生素治疗；143例患者未接受抗生素治疗。接受抗生素治疗的患者白细胞扫描敏感性为88.7%；未接受抗生素治疗的患者为92.1%。两组之间的敏感性差异无统计学意义（p小于0.05）。我们得出结论，抗生素治疗不会影响铟 - 111标记的白细胞扫描的敏感性。
