Pediatric Surgery, Kasturba Medical College Manipal, Manipal academy of Higher education, Manipal, Karnataka, India.
Pediatric Surgery, Kasturba Medical College Manipal, Manipal academy of Higher education, Manipal, Karnataka, India
BMJ Case Rep. 2023 Oct 13;16(10):e256505. doi: 10.1136/bcr-2023-256505.
An inflammatory myofibroblastic tumour (IMT) is an uncommon neoplasm composed of inflammatory cells and myofibroblasts in a fibrous stroma. They are mostly seen in the lungs and rarely involve the gastrointestinal tract. An 8-month-old infant presented with a history of lower abdominal lump for 2 months. Her CT scan confirmed a large, lobulated mass in the retroperitoneum arising from the pelvis. The mass was found to be arising from the sigmoid colon on laparotomy which was excised. Histopathology showed a cellular tumour composed of spindle cells and inflammatory lymphocytic infiltrate. Immunohistochemistry revealed positive staining for anaplastic lymphoma kinase and smooth muscle actin, confirming the diagnosis of IMT. The patient is doing well at her 6-month follow-up. Ours is the youngest case of sigmoid IMT among the only other series of eight cases reported in the literature indicating its rarity.
炎性肌纤维母细胞瘤（IMT）是一种少见的肿瘤，由纤维基质中的炎症细胞和肌纤维母细胞组成。它们主要见于肺部，很少累及胃肠道。一名 8 月龄婴儿因下腹肿块 2 个月就诊。CT 扫描证实其腹膜后有一个来自骨盆的大分叶状肿块。剖腹探查发现肿块起源于乙状结肠并将其切除。组织病理学显示由梭形细胞和炎症性淋巴细胞浸润组成的细胞性肿瘤。免疫组化显示间变性淋巴瘤激酶和平滑肌肌动蛋白阳性染色，确诊为 IMT。患者在 6 个月的随访中情况良好。我们的病例是文献中仅有的 8 例乙状结肠 IMT 中年龄最小的病例，表明其罕见。
