Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine Greifswald, Greifswald, Germany.
Clin Chem Lab Med. 2023 Oct 16;62(4):657-663. doi: 10.1515/cclm-2023-0632. Print 2024 Mar 25.
Many hospitals use pneumatic tube systems (PTS) for transport of diagnostic samples. Continuous monitoring of PTS and evaluation prior to clinical use is recommended. Data loggers with specifically developed algorithms have been suggested as an additional tool in PTS evaluation. We compared two different data loggers.
Transport types - courier, conventional (cPTS) and innovative PTS (iPTS) - were monitored using two data loggers (MSR145 logger, CiK Solutions GmbH, Karlsruhe, Germany, and a prototype developed at the University Medicine Greifswald). Data loggers differ in algorithm, recording frequencies and limit of acceleration detection. Samples from apparently healthy volunteers were split among the transport types and results for 37 laboratory measurands were compared.
For each logger specific arbitrary units were calculated. Area-under-the-curve (AUC)-values (MSR145) were lowest for courier and highest for iPTS and increased with increasing recording frequencies. Stress (St)-values (prototype logger) were obtained in kmsu (1,000*mechanical stress unit) and were highest for iPTS as well. Statistical differences between laboratory measurement results of transport types were observed for three measurands sensitive for hemolysis.
The statistical, but not clinical, differences in the results for hemolysis sensitive measurands may be regarded as an early sign of preanalytical impairment. Both data loggers record this important interval of beginning mechanical stress with a high resolution indicating their potential to facilitate early detection of preanalytical impairment. Further studies should identify suitable recording frequencies. Currently, evaluation and monitoring of diagnostic sample transport should not only rely on data loggers but also include diagnostic samples.
许多医院使用气动输送系统（PTS）来运输诊断样本。建议在临床使用前对 PTS 进行连续监测和评估。具有专门开发算法的数据记录仪已被提议作为 PTS 评估的附加工具。我们比较了两种不同的数据记录仪。
使用两种数据记录仪（MSR145 记录仪，CiK 解决方案有限公司，卡尔斯鲁厄，德国和格赖夫斯瓦尔德大学开发的原型）监测运输类型-快递员、常规（cPTS）和创新 PTS（iPTS）。数据记录仪在算法、记录频率和加速度检测极限方面存在差异。来自健康志愿者的样本被分配到不同的运输类型中，并比较了 37 个实验室测量结果。
为每个记录仪计算了特定的任意单位。MSR145 的曲线下面积（AUC）值最低的是快递员，最高的是 iPTS，且随着记录频率的增加而增加。原型记录仪的应力（St）值以 kmsu（1000*机械应力单位）表示，iPTS 的值最高。对于三个对溶血敏感的测量值，在运输类型的实验室测量结果之间观察到了统计学差异。
溶血敏感测量值的结果存在统计学差异，但无临床差异，这可能被视为分析前受损的早期迹象。两种数据记录仪都以高分辨率记录这段重要的起始机械应力间隔，表明它们具有促进分析前受损早期检测的潜力。进一步的研究应确定合适的记录频率。目前，诊断样本运输的评估和监测不仅应依赖于数据记录仪，还应包括诊断样本。
