小分子 BDNF 模拟二肽 GSB-106 与 TRK 受体相互作用的药物遗传学分析。
Pharmacogenetic Analysis of the Interaction of the Low-Molecular-Weight BDNF Mimetic Dipeptide GSB-106 with TRK Receptors.
机构信息
Zakusov Research Institute of Pharmacology, Moscow, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
出版信息
Dokl Biochem Biophys. 2023 Aug;511(1):166-168. doi: 10.1134/S1607672923700230. Epub 2023 Oct 13.
PMID:37833601
Abstract
Using TrkA or TrkB receptor gene knockout HT-22 cells, the selectivity of the interaction of the low-molecular-weight dipeptide BDNF mimetic GSB-106 (hexamethylenediamide bis(N-monosuccinyl-L-seryl-L-lysine)) with TrkB receptors was shown.
摘要
利用 TrkA 或 TrkB 受体基因敲除 HT-22 细胞，研究了低分子量二肽 BDNF 模拟物 GSB-106（己二胺双（N-单琥珀酰基-L-丝氨酰-L-赖氨酰））与 TrkB 受体相互作用的选择性。
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