Nakazato Y, Landing B H, Wells T R
J Pediatr Surg. 1986 Oct;21(10):831-7. doi: 10.1016/s0022-3468(86)80002-1.
The Auerbach plexus of the upper gastrointestinal tract of five patients with esophageal atresia and tracheoesophageal fistula (EA-TEF) who had not had surgical reconstruction of the esophagus was studied by a microdissection technique to investigate the etiology of dysphagia, gastroesophageal reflux, and delayed gastric emptying; common findings in patients with repaired EA-TEF. All five patients showed a looser than normal Auerbach plexus in the distal esophagus, and to a lesser degree in the proximal esophagus, confirmed by point-count morphometric studies. The Auerbach plexus of the gastric fundus of all the patients was also abnormal. These findings suggest the existence of congenital functional impairment of the upper gastrointestinal tract in patients with EA-TEF, due to abnormal development of the myenteric plexus.
采用显微解剖技术对5例未行食管重建手术的食管闭锁合并气管食管瘘（EA-TEF）患者的上消化道奥尔巴赫神经丛进行了研究，以探讨吞咽困难、胃食管反流和胃排空延迟的病因；这些是食管闭锁合并气管食管瘘修复术后患者的常见表现。所有5例患者经点计数形态计量学研究证实，食管远端的奥尔巴赫神经丛比正常情况更为疏松，食管近端的程度较轻。所有患者胃底的奥尔巴赫神经丛也均异常。这些发现提示，食管闭锁合并气管食管瘘患者存在上消化道先天性功能障碍，这是由于肌间神经丛发育异常所致。
