Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Rende, CS, Italy.
Centro Sanitario, University of Calabria, Via P Bucci, Rende, CS, Italy.
J Transl Med. 2023 Oct 13;21(1):718. doi: 10.1186/s12967-023-04571-z.
The complex interplay between health, lifestyle and genetics represents a critical area of research for understanding and promoting human well-being. Importantly, genetics plays a key role in determining individual susceptibility to disease and response to lifestyle. The aim of the present study was to identify genetic factors related to the metabolic/inflammatory profile of adolescents providing new insights into the individual predisposition to the different effects of the substances from the environment.
Association analysis of genetic variants and biochemical parameters was performed in a total of 77 healthy adolescents recruited in the context of the DIMENU study.
Polymorphisms of 3-hydroxy-3-methylglutaril coenzyme A reductase (HMGCR; rs142563098), C-reactive protein gene (CRP; rs1417938, rs1130864), cholesteryl ester transfer protein (CETP; rs5030708), interleukin (IL)-10 (IL-10; rs3024509) genes were significantly associated (p < 0.05) with various serum metabolic parameters. Of particular interest were also the correlations between the HMGCRpolymorphism (rs3846663) and tumor necrosis factor (TNF)-α levels, as well Fatty-acid desaturase (FADS) polymorphism (rs7481842) and IL-10 level opening a new link between lipidic metabolism genes and inflammation.
In this study, we highlighted associations between single nucleotide polymorphisms (SNPs) and serum levels of metabolic and inflammatory parameters in healthy young individuals, suggesting the importance of genetic profiling in the prevention and management of chronic disease.
健康、生活方式和遗传之间的复杂相互作用是理解和促进人类健康的关键研究领域。重要的是，遗传在决定个体对疾病的易感性和对生活方式的反应方面起着关键作用。本研究的目的是确定与青少年代谢/炎症特征相关的遗传因素，为个体对环境物质的不同影响的易感性提供新的见解。
在 DIMENU 研究中，共对 77 名健康青少年进行了遗传变异与生化参数的关联分析。
3-羟-3-甲基戊二酰辅酶 A 还原酶（HMGCR；rs142563098）、C 反应蛋白基因（CRP；rs1417938、rs1130864）、胆固醇酯转移蛋白（CETP；rs5030708）、白细胞介素（IL）-10（IL-10；rs3024509）基因的多态性与各种血清代谢参数显著相关（p<0.05）。特别值得注意的是，HMGCR 多态性（rs3846663）与肿瘤坏死因子（TNF）-α水平之间的相关性，以及脂肪酸去饱和酶（FADS）多态性（rs7481842）与 IL-10 水平之间的相关性，为脂质代谢基因与炎症之间的新联系提供了证据。
在这项研究中，我们强调了单核苷酸多态性（SNPs）与健康年轻个体血清代谢和炎症参数水平之间的关联，表明遗传谱分析在预防和管理慢性疾病方面的重要性。
