脑胶质母细胞瘤环状 RNA 组学。

The Glioblastoma CircularRNAome.

机构信息

Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, Romania.

The Oncology Institute "Prof. Dr. Ion Chiricuta", 400015 Cluj-Napoca, Romania.

出版信息

Int J Mol Sci. 2023 Sep 26;24(19):14545. doi: 10.3390/ijms241914545.

DOI:10.3390/ijms241914545

PMID:37833993

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10572686/

Abstract

Glioblastoma remains one of the most aggressive cancers of the brain, warranting new methods for early diagnosis and more efficient treatment options. Circular RNAs (circRNAs) are rather new entities with increased stability compared to their linear counterparts that interact with proteins and act as microRNA sponges, among other functions. Herein, we provide a critical overview of the recently described glioblastoma-related circRNAs in the literature, focusing on their roles on glioblastoma cancer cell proliferation, survival, migration, invasion and metastasis, metabolic reprogramming, and therapeutic resistance. The main roles of circRNAs in regulating cancer processes are due to their regulatory roles in essential oncogenic pathways, including MAPK, PI3K/AKT/mTOR, and Wnt, which are influenced by various circRNAs. The present work pictures the wide implication of circRNAs in glioblastoma, thus highlighting their potential as future biomarkers and therapeutic targets/agents.

摘要

胶质母细胞瘤仍然是最具侵袭性的脑癌之一，需要新的方法进行早期诊断和更有效的治疗选择。环状 RNA（circRNA）是一种新型实体，与线性 RNA 相比具有更高的稳定性，可与蛋白质相互作用并充当 microRNA 海绵等，具有多种功能。在此，我们对文献中最近描述的与胶质母细胞瘤相关的 circRNA 进行了批判性概述，重点介绍了它们在胶质母细胞瘤癌细胞增殖、存活、迁移、侵袭和转移、代谢重编程和治疗耐药性方面的作用。circRNA 在调节癌症过程中的主要作用是由于它们在包括 MAPK、PI3K/AKT/mTOR 和 Wnt 在内的重要致癌途径中的调节作用，这些途径受多种 circRNA 的影响。本工作描绘了 circRNA 在胶质母细胞瘤中的广泛意义，从而突出了它们作为未来生物标志物和治疗靶点/药物的潜力。