Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Int J Mol Sci. 2023 Sep 27;24(19):14653. doi: 10.3390/ijms241914653.
Nonalcoholic fatty liver disease (NAFLD) is a progressive condition that encompasses a spectrum of liver disorders, beginning with the simple steatosis, progressing to nonalcoholic steatohepatitis (NASH), and possibly leading to more severe diseases, including liver cirrhosis and hepatocellular carcinoma (HCC). In recent years, the prevalence of NAFLD has increased due to a shift towards energy-dense dietary patterns and a sedentary lifestyle. NAFLD is also strongly associated with metabolic disorders such as obesity and hyperlipidemia. The progression of NAFLD could be influenced by a variety of factors, such as diet, genetic factors, and even epigenetic factors. In contrast to genetic factors, epigenetic factors, including histone modifications, exhibit dynamic and reversible features. Therefore, the epigenetic regulation of the initiation and progression of NAFLD is one of the directions under intensive investigation in terms of pathogenic mechanisms and possible therapeutic interventions. This review aims to discuss the possible mechanisms and the crucial role of histone modifications in the framework of epigenetic regulation in NAFLD, which may provide potential therapeutic targets and a scientific basis for the treatment of NAFLD.
非酒精性脂肪性肝病（NAFLD）是一种进行性疾病，涵盖了一系列肝脏疾病，从单纯性脂肪变性开始，进展为非酒精性脂肪性肝炎（NASH），并可能导致更严重的疾病，包括肝硬化和肝细胞癌（HCC）。近年来，由于能量密集型饮食模式和久坐不动的生活方式的转变，NAFLD 的患病率有所增加。NAFLD 还与肥胖和高脂血症等代谢紊乱密切相关。NAFLD 的进展可能受到多种因素的影响，如饮食、遗传因素甚至表观遗传因素。与遗传因素不同，表观遗传因素，包括组蛋白修饰，具有动态和可逆的特征。因此，NAFLD 发病机制和可能的治疗干预措施的研究热点之一是探讨组蛋白修饰在 NAFLD 中启动和进展的表观遗传调控中的可能机制和关键作用。本综述旨在讨论组蛋白修饰在 NAFLD 表观遗传调控中的可能机制和关键作用，这可能为 NAFLD 的治疗提供潜在的治疗靶点和科学依据。
