Colvett Isaac, Gilmore Anah, Guzman Samuel, Ledreux Aurélie, Quintero Jorge E, Ginjupally Dhanunjaya Rao, Gurwell Julie A, Slevin John T, Guduru Zain, Gerhardt Greg A, van Horne Craig G, Granholm Ann-Charlotte
Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
J Clin Med. 2023 Sep 22;12(19):6121. doi: 10.3390/jcm12196121.
Parkinson's disease (PD) is a severe neurological disease for which there is no effective treatment or cure, and therefore it remains an unmet need in medicine. We present data from four participants who received autologous transplantation of small pieces of sural nerve tissue into either the basal forebrain containing the nucleus basalis of Meynert (NBM) or the midbrain substantia nigra (SN). The grafts did not exhibit significant cell death or severe host-tissue reaction up to 55 months post-grafting and contained peripheral cells. Dopaminergic neurites showed active growth in the graft area and into the graft in the SN graft, and cholinergic neurites were abundant near the graft in the NBM. These results provide a histological basis for changes in clinical features after autologous peripheral nerve tissue grafting into the NBM or SN in PD.
帕金森病（PD）是一种严重的神经疾病，目前尚无有效的治疗方法或治愈手段，因此仍是医学上未被满足的需求。我们展示了四名参与者的数据，他们接受了将小块腓肠神经组织自体移植到含有Meynert基底核（NBM）的基底前脑或中脑黑质（SN）的手术。移植后长达55个月，移植物未表现出明显的细胞死亡或严重的宿主组织反应，且含有外周细胞。多巴胺能神经突在移植区域有活跃生长，并在SN移植物中长入移植物，胆碱能神经突在NBM移植物附近丰富。这些结果为PD患者将自体周围神经组织移植到NBM或SN后临床特征的变化提供了组织学依据。
