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不同类型血管炎合并肝素诱导的血小板减少症——4例分析及文献复习

Different Types of Vasculitis Complicated by Heparin-Induced Thrombocytopenia-Analysis of Four Cases and Literature Review.

作者信息

Rytel Adam, Nowak Mateusz, Kukawska-Rytel Monika, Morawiec Katarzyna, Niemczyk Stanisław

机构信息

Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland.

出版信息

J Clin Med. 2023 Sep 24;12(19):6176. doi: 10.3390/jcm12196176.

Abstract

Vasculitis and HIT have different etiologies, although both involve autoimmune mechanisms. Treatment of vasculitis often requires the use of an anticoagulant such as heparin, which can lead to the development of HIT and subsequent life-threatening complications. The analysis covered patients hospitalized in the Department of Internal Medicine, Nephrology and Dialysis in the period from September 2020 to March 2023. After analyzing the data, we selected four patients in whom vasculitis treatment was complicated by HIT. These included two patients with ANCA vasculitis and two patients with anti-GBM disease. We also described similar cases reported in the literature.

摘要

血管炎和肝素诱导的血小板减少症(HIT)病因不同,尽管两者都涉及自身免疫机制。血管炎的治疗通常需要使用抗凝剂,如肝素,这可能导致HIT的发生以及随后危及生命的并发症。该分析涵盖了2020年9月至2023年3月期间在内科、肾脏病学和透析科住院的患者。在分析数据后,我们选择了4例血管炎治疗并发HIT的患者。其中包括2例抗中性粒细胞胞浆抗体(ANCA)血管炎患者和2例抗肾小球基底膜(GBM)病患者。我们还描述了文献中报道的类似病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bbd/10573553/685b900cf5bd/jcm-12-06176-g001.jpg

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