Stone Margot A, Lissenberg-Witte Birgit I, de Bree Remco, Hardillo Jose A, Lamers Femke, Langendijk Johannes A, Leemans C René, Takes Robert P, Jansen Femke, Verdonck-de Leeuw Irma M
Department Otolaryngology-Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Cancer Center Amsterdam, Treatment and Quality of Life, 1081 HV Amsterdam, The Netherlands.
Cancers (Basel). 2023 Sep 27;15(19):4755. doi: 10.3390/cancers15194755.
The aim of this study was to investigate changes in sexuality and sexual dysfunction in head and neck cancer (HNC) patients in the first two years after treatment, in relation to the type of treatment. Data were used of 588 HNC patients participating in the prospective NETherlands Quality of life and Biomedical Cohort Study (NET-QUBIC) from diagnosis to 3, 6, 12 and 24 months after treatment. Primary outcome measures were the International Index of Erectile Function (IIEF) and the Female Sexual Function Index (FSFI). The total scores of the IIEF and FSFI were dichotomized into sexual (dys)function. In men, type of treatment was significantly associated with change in erectile function, orgasm, satisfaction with intercourse, and overall satisfaction. In women, type of treatment was significantly associated with change in desire, arousal, and orgasm. There were significant differences between treatment groups in change in dysfunctional sexuality. A deterioration in sexuality and sexual dysfunction from baseline to 3 months after treatment was observed especially in patients treated with chemoradiation. Changes in sexuality and sexual dysfunction in HNC patients were related to treatment, with an acute negative effect of chemoradiation. This effect on the various domains of sexuality seems to differ between men and women.
本研究的目的是调查头颈癌（HNC）患者在治疗后的头两年内性功能和性功能障碍的变化情况，并探讨其与治疗类型的关系。研究数据来自588名头颈癌患者，这些患者参与了前瞻性荷兰生活质量与生物医学队列研究（NET-QUBIC），从诊断开始随访至治疗后3、6、12和24个月。主要结局指标为国际勃起功能指数（IIEF）和女性性功能指数（FSFI）。IIEF和FSFI的总分被二分法分为性功能（障碍）。在男性中，治疗类型与勃起功能、性高潮、性交满意度和总体满意度的变化显著相关。在女性中，治疗类型与性欲、性唤起和性高潮的变化显著相关。治疗组之间在性功能障碍的变化方面存在显著差异。尤其是接受放化疗的患者，从基线到治疗后3个月，性功能以及性功能障碍出现了恶化。头颈癌患者的性功能和性功能障碍变化与治疗有关，放化疗具有急性负面影响。这种对性功能各个领域的影响在男性和女性中似乎有所不同。
