Department of Otorhinolaryngology-Head and Neck Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Karolinska University Hospital, Stockholm, Sweden.
Head Neck. 2021 Dec;43(12):3843-3856. doi: 10.1002/hed.26882. Epub 2021 Sep 24.
This exploratory, registry-based, cross-sectional study aimed to evaluate patients' health-related quality of life (HRQOL) in a subsite of oropharyngeal cancer: cancer of the base of the tongue (CBT).
CBT patients, treated with curative intent, completed the EORTC QLQ-C30 and QLQ-H&N35 questionnaires 15 months after diagnosis. The HRQOL of CBT patients was compared to reference scores from the general population and to that of tonsillar carcinoma patients.
The 190 CBT patients scored significantly worse than members of the general population on most scales. CBT patients with human papilloma virus (HPV)-positive tumors had significantly better HRQOL on 8 of 28 scales than HPV-negative patients. Compared to 405 tonsillar carcinoma patients, CBT patients had significantly worse HRQOL on 8 of the 28 scales, the majority local head and neck related problems.
One year after treatment, CBT patients' HRQOL was significantly worse in many areas compared to that of the general population and slightly worse than that of tonsillar carcinoma patients.
本探索性、基于登记的、横断面研究旨在评估口咽癌亚部位（舌根癌）患者的健康相关生活质量（HRQOL）。
接受根治性治疗的舌根癌患者在诊断后 15 个月完成 EORTC QLQ-C30 和 QLQ-H&N35 问卷。将舌根癌患者的 HRQOL 与一般人群的参考评分和扁桃体癌患者的 HRQOL 进行比较。
190 例舌根癌患者在大多数量表上的评分明显低于一般人群。HPV 阳性肿瘤的舌根癌患者在 28 个量表中的 8 个量表上的 HRQOL 明显优于 HPV 阴性患者。与 405 例扁桃体癌患者相比，舌根癌患者在 28 个量表中的 8 个量表上的 HRQOL 明显较差，大多数与局部头颈部相关问题有关。
治疗 1 年后，与一般人群相比，舌根癌患者在许多方面的 HRQOL 明显较差，略差于扁桃体癌患者。
