Gallant Jean-Nicolas, Weiss Vivian L, Chen Sheau-Chiann, Liang Jiancong, Belcher Ryan H, Ye Fei, Correa Hernan, Wang Huiying
Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Cancers (Basel). 2023 Oct 9;15(19):4902. doi: 10.3390/cancers15194902.
The association between Hashimoto's thyroiditis (HT) and pediatric thyroid cancer is controversial. Most studies examining this connection have been based on adults, and larger studies in children are lacking. We performed a retrospective study of all sequential pediatric patients who underwent a thyroidectomy for a neoplasm at our institution over a twenty-year period in order to explore the link between HT and pediatric thyroid cancer. A total of 153 patients, median age 16.5 (interquartile range [IQR] 14.2-18.3) years, underwent thyroid surgery for a neoplasm. Patients were mainly female (80%) and White (84%). Median follow-up was 58.6 (IQR 20.7-105.4) months. Thirty-five (23%) patients had HT. Patients who underwent thyroid surgery and had HT were more likely to harbor a malignant neoplasm ( = 0.05); specifically, papillary thyroid carcinoma (PTC, = 0.02). There was a difference in the distribution of HT among the subtypes of PTC ( = 0.03). Despite this, there was no difference in terms of survival between patients with/without HT. In conclusion, children with a thyroid malignancy, specifically, PTC, are more likely to have HT. The association between HT and pediatric PTC appears to be subtype-specific but does not seem to affect patient survival.
桥本甲状腺炎（HT）与儿童甲状腺癌之间的关联存在争议。大多数研究这种关联的研究都是基于成人，缺乏针对儿童的大型研究。我们对在我们机构20年期间因肿瘤接受甲状腺切除术的所有连续儿科患者进行了一项回顾性研究，以探讨HT与儿童甲状腺癌之间的联系。共有153例患者接受了因肿瘤的甲状腺手术，中位年龄16.5岁（四分位间距[IQR]为14.2 - 18.3岁）。患者主要为女性（80%）和白人（84%）。中位随访时间为58.6个月（IQR为20.7 - 105.4个月）。35例（23%）患者患有HT。接受甲状腺手术且患有HT的患者更有可能患有恶性肿瘤（P = 0.05）；具体而言，甲状腺乳头状癌（PTC，P = 0.02）。PTC各亚型中HT的分布存在差异（P = 0.03）。尽管如此，有/无HT的患者在生存方面没有差异。总之，患有甲状腺恶性肿瘤的儿童，特别是PTC患者，更有可能患有HT。HT与儿童PTC之间的关联似乎具有亚型特异性，但似乎不影响患者生存。
