Morris J A, Bird C C
Cancer. 1979 Jul;44(1):171-82. doi: 10.1002/1097-0142(197907)44:1<171::aid-cncr2820440129>3.0.co;2-e.
The first case of immunoblastic lymphadenopathy developing in a child which progressed to immunoblastic sarcoma is reported. The sarcoma cells showed light and electron microscopic features of transformed lymphocytes (immunoblasts) but it was not possible to establish their B-cell origin using a peroxidase-antiperoxidase technique for the demonstration of intracellular immunoglobulins. In the affected lymph nodes there was marked proliferation of reticulum and endothelial cells both of which contained numerous intranuclear inclusions which may be of viral origin. Ultrastructural studies suggest that the amorphous eosinophilic interstitial material, an important diagnostic morphological feature of immunoblastic lymphadenopahy, results from the oblique sectioning of the elongated and branching cytoplasmic processes of reticulum cells. It is postulated that in immunoblastic lymphadenopathy the proliferation of reticulum and endothelial cells may be the primary event, perhaps stimulated by viral infection and that the intense lymphocytic and plasmacytic infiltration and sarcomatous transformation occur as secondary phenomena.
本文报告了首例发生于儿童的免疫母细胞性淋巴结病，并进展为免疫母细胞肉瘤。肉瘤细胞呈现出转化淋巴细胞（免疫母细胞）的光镜和电镜特征，但采用过氧化物酶-抗过氧化物酶技术来显示细胞内免疫球蛋白，却无法确定其B细胞来源。在受累淋巴结中，网状细胞和内皮细胞显著增生，两者均含有大量可能源于病毒的核内包涵体。超微结构研究表明，免疫母细胞性淋巴结病的重要诊断形态学特征——无定形嗜酸性间质物质，是网状细胞伸长且分支的胞质突起斜切所致。据推测，在免疫母细胞性淋巴结病中，网状细胞和内皮细胞的增生可能是主要事件，或许由病毒感染所激发，而强烈的淋巴细胞和浆细胞浸润以及肉瘤样转化则是继发现象。
