12个患有脆性X染色体（q27）的家庭。
Twelve families with fragile X(q27).
作者信息
Webb T, Thake A, Todd J
出版信息
J Med Genet. 1986 Oct;23(5):400-6. doi: 10.1136/jmg.23.5.400.
Abstract
Through a community study of boys requiring special education for the severely mentally retarded, 12 families were ascertained in which the fragile X was found to be segregating. By assiduous follow up of these families, it was found that in only four of them could male transmission be ruled out from the grandparents' or great grandparents' generation and that the segregation ratios are disturbed.
摘要
通过对需要为重度智力迟钝男孩提供特殊教育的社区研究，确定了12个家庭，其中发现脆性X染色体正在分离。通过对这些家庭的不懈追踪，发现其中只有4个家庭可以排除从祖父母或曾祖父母一代开始的男性遗传，而且分离比例受到干扰。
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