Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.
Nutrients. 2023 Sep 28;15(19):4193. doi: 10.3390/nu15194193.
There is evidence that the association of protein intake and frailty may depend on the source of dietary protein. The mechanism underlying this association is not clear. In this study, we explore circulating metabolites as mediators of the relationship between dietary protein and of frailty in participants of the Baltimore Longitudinal Study of Aging (BLSA). Cross-sectional analyses in 735 BLSA participants of associations between plant and animal protein intake and frailty. Usual protein intake from plant and animal sources were estimated with a Food Frequency Questionnaire (FFQ) and frailty was assessed with a 44-item Frailty Index (FI). Compared with the lowest quartile, higher quartiles of plant, but not animal, protein were associated with lower FI. Twenty-five plasma metabolites were associated with plant protein intake; of these, fifteen, including phosphatidylcholines, cholesterol esters, sphingomyelins, and indole metabolites, mediated the association between plant protein intake and FI. The protective association between plant protein consumption and FI is mediated by lower abundance of lipid metabolites and higher abundance of tryptophan-related metabolites.
有证据表明，蛋白质摄入量与虚弱之间的关联可能取决于饮食蛋白质的来源。这种关联的机制尚不清楚。在这项研究中，我们探索了循环代谢物作为饮食蛋白质与巴尔的摩纵向衰老研究（BLSA）参与者虚弱之间关系的中介物。在 735 名 BLSA 参与者中进行了横断面分析，以研究植物蛋白和动物蛋白摄入与虚弱之间的关联。使用食物频率问卷（FFQ）估计来自植物和动物来源的通常蛋白质摄入量，并使用 44 项虚弱指数（FI）评估虚弱程度。与最低四分位数相比，较高的植物蛋白四分位数与较低的 FI 相关，但动物蛋白则不然。与植物蛋白摄入相关的 25 种血浆代谢物；其中，包括磷脂酰胆碱、胆固醇酯、神经鞘磷脂和吲哚代谢物在内的 15 种代谢物，介导了植物蛋白摄入与 FI 之间的关联。植物蛋白摄入与 FI 之间的保护关联是由脂质代谢物丰度降低和色氨酸相关代谢物丰度升高介导的。
