蛋白质摄入与虚弱的相关性存在性别差异：基于老年人健康问卷指标评估。

Sex Difference in the Association Between Protein Intake and Frailty: Assessed Using the Kihon Checklist Indexes Among Older Adults.

机构信息

Section of Healthy Longevity Research, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan; Department of Health and Sports Sciences, Kyoto Gakuen University, Kyoto, Japan.

出版信息

J Am Med Dir Assoc. 2018 Sep;19(9):801-805. doi: 10.1016/j.jamda.2018.04.005. Epub 2018 Jun 1.

DOI:10.1016/j.jamda.2018.04.005

PMID:29861193

Abstract

BACKGROUND

Dietary protein intake is inversely associated with physical frailty risk. However, it is unknown whether an association exists between dietary protein intake and comprehensive frailty.

OBJECTIVE

To evaluate the association between protein intake and comprehensive frailty in older Japanese adults.

DESIGN, SETTING AND PARTICIPANTS: This cross-sectional study included 5638 Japanese participants (2707 men and 2931 women) aged ≥65 years from Kameoka City, Kyoto, Japan.

MEASUREMENTS

Dietary intake was estimated using a validated self-administered food frequency questionnaire. Comprehensive frailty was assessed using a 25-item Kihon Checklist (KCL), which comprised instrumental activities of daily living, mobility disability, malnutrition, oral or eating function, socialization and housebound, cognitive function, and depression domains. A KCL score of 4 to 6 was defined as prefrailty, and ≥7 as frailty.

RESULTS

In women, but not in men, protein intake showed a lower prevalence for prefrailty (Q1-Q4, 40.2%, 34.3%, 34.3%, and 36.0%). Higher protein intake was associated with lower prevalence of frailty both in men (32.5%, 28.4%, 28.3%, and 27.3%) and women (35.7%, 31.4%, 27.6%, and 28.2%). Moreover, higher dietary protein intake decreased the odds ratio (OR) for frailty after adjustment for potential confounding factors in both men (OR for highest vs lowest quartile, 0.62; 95% CI, 0.43-0.89; P for trend = 0.016) and women (OR 0.64; 95% CI, 0.45-0.91; P for trend = 0.017).

CONCLUSIONS/IMPLICATIONS: The higher dietary protein intake may be inversely associated with the prevalence of comprehensive frailty in Japanese men and women. Future studies are needed to examine associations of dietary protein intake within KCL domains.

摘要

背景

膳食蛋白质摄入量与身体虚弱风险呈负相关。然而，目前尚不清楚膳食蛋白质摄入量与综合虚弱之间是否存在关联。

目的

评估日本老年人蛋白质摄入量与综合虚弱的关系。

设计、地点和参与者：本横断面研究纳入了来自日本京都府龟冈市的 5638 名年龄≥65 岁的日本参与者（男性 2707 人，女性 2931 人）。

测量

使用经过验证的自我管理食物频率问卷评估膳食摄入量。使用 25 项 Kihon Checklist（KCL）评估综合虚弱，包括日常生活活动工具性能力、移动能力障碍、营养不良、口腔或进食功能、社交和居家、认知功能和抑郁领域。KCL 得分为 4-6 定义为虚弱前期，≥7 定义为虚弱。

结果

在女性中，但在男性中没有，蛋白质摄入量与虚弱前期的患病率较低相关（Q1-Q4，40.2%、34.3%、34.3%和 36.0%）。较高的蛋白质摄入量与男性（32.5%、28.4%、28.3%和 27.3%）和女性（35.7%、31.4%、27.6%和 28.2%）的虚弱患病率降低相关。此外，较高的膳食蛋白质摄入量降低了调整潜在混杂因素后的男性（最高与最低四分位数的比值比[OR]，0.62；95%置信区间[CI]，0.43-0.89；P 趋势=0.016）和女性（OR 0.64；95%CI，0.45-0.91；P 趋势=0.017）虚弱的比值比。

结论/意义：较高的膳食蛋白质摄入量可能与日本男性和女性综合虚弱的患病率呈负相关。需要进一步研究来检验 KCL 各领域内的膳食蛋白质摄入量的相关性。