Busch F W, Seid D A, Wei E T
Cancer Lett. 1979 May;6(6):319-24. doi: 10.1016/s0304-3835(79)80088-9.
Smoke condensates prepared from marihuana cigaretts were mutagenic in strain TA98 of the Ames Salmonella/microsome test, a short-term bioassay which estimates the mutagenic and carcinogenic potential of some chemicals. The mutagens in marihuana smoke condensates required liver enzymes to be activated. The specific mutagenic activity of marihuana smoke condensates were similar to that of tobacco smoke condensates prepared from American cigarettes. Fractionation studies of the marihuana smoke condensates showed that basic components accounted for 76% of the recovered mutagenic activity.
从大麻香烟制备的烟雾浓缩物在艾姆斯沙门氏菌/微粒体试验的TA98菌株中具有致突变性，这是一种短期生物测定法，用于评估某些化学物质的诱变和致癌潜力。大麻烟雾浓缩物中的诱变剂需要肝脏酶来激活。大麻烟雾浓缩物的比致突变活性与从美国香烟制备的烟草烟雾浓缩物相似。对大麻烟雾浓缩物的分级研究表明，碱性成分占回收的诱变活性的76%。
