由4-氨基-四氢吡啶亚基盐形成5-氨甲基-2,3-二氢吡啶-4(1)-酮。

Formation of 5-Aminomethyl-2,3-dihydropyridine-4(1)-ones from 4-Amino-tetrahydropyridinylidene Salts.

作者信息

Seebacher Werner, Hoffelner Michael, Belaj Ferdinand, Pirker Teresa, Alajlani Muaaz, Bauer Rudolf, Pferschy-Wenzig Eva-Maria, Saf Robert, Weis Robert

机构信息

Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Schubertstrasse 1, 8010 Graz, Austria.

Institute of Chemistry, University of Graz, Schubertstrasse 1, 8010 Graz, Austria.

出版信息

Molecules. 2023 Sep 29;28(19):6869. doi: 10.3390/molecules28196869.

Various 4-aminotetrahydropyridinylidene salts were treated with aldehydes in an alkaline medium. Their conversion to 5-substituted β-hydroxyketones in a one-step reaction succeeded only with an aliphatic aldehyde. Instead, aromatic aldehydes gave 5-substituted β-aminoketones or a single δ-diketone. The new compounds were characterized using spectroscopic methods and a single crystal structure analysis. Some of them showed anticancer and antibacterial properties.