Department of Clinical Dentistry, Section of Periodontics, University of Bergen, Bergen, Norway.
Department of Clinical Science, University of Bergen, Bergen, Norway.
J Clin Periodontol. 2024 Jan;51(1):86-96. doi: 10.1111/jcpe.13886. Epub 2023 Oct 14.
To investigate the association between periodontitis and lung function in the Malmö Offspring Dental Study.
In all 1001 individuals (49.9% female, mean age: 44.6) from Malmö Offspring Dental Study were included. Periodontitis was assessed by a full-mouth examination protocol including bleeding on probing and classified according to the American Academy of Periodontology/Center for Disease Control definitions. Forced expiratory volume in 1 s (FEV ) and forced vital capacity (FVC) were expressed as absolute values and %predicted according to Global Lung Function Initiative reference values. FEV , FVC and FEV /FVC were analysed in relation to periodontal status using linear regression.
Severe periodontitis was found in 7% of the population. Adjusted regression models showed significant associations between lung function and severe periodontitis with 2.1 unit lower FEV /FVC ratio (95% CI: -3.91, -0.23) and odds ratio (adjusted) of 2.56 (95% CI: 1.40, 4.75, p = .003) for airflow obstruction (FEV /FVC less than the lower limit of normal) if having severe periodontitis. Lower values of %predicted FEV and %predicted FVC, but not FEV /FVC, were found in individuals with >25% bleeding on probing.
Severe periodontitis was associated with lower FEV /FVC ratio and airflow obstruction in the present cohort. More large-scale prospective studies and intervention studies are required for a comprehensive evaluation.
在马尔默后代牙科研究中调查牙周炎与肺功能之间的关系。
本研究纳入了来自马尔默后代牙科研究的 1001 名个体（49.9%为女性，平均年龄：44.6 岁）。牙周炎通过全口检查方案进行评估，包括探诊出血，并根据美国牙周病学会/疾病控制中心的定义进行分类。1 秒用力呼气容积（FEV ）和用力肺活量（FVC）均表示为绝对值，并根据全球肺功能倡议参考值表示为预计值的百分比。使用线性回归分析牙周状况与 FEV 、FVC 和 FEV / FVC 的关系。
7%的人群患有严重牙周炎。调整后的回归模型显示，肺功能与严重牙周炎之间存在显著关联，FEV / FVC 比值降低 2.1 个单位（95%CI：-3.91，-0.23），气流阻塞（FEV / FVC 低于正常下限）的比值比（调整后）为 2.56（95%CI：1.40，4.75，p = 0.003）。如果患有严重牙周炎，个体的 %predicted FEV 和 %predicted FVC 值较低，但 FEV / FVC 比值没有降低。在探诊出血>25%的个体中，发现 %predicted FEV 和 %predicted FVC 值较低，但 FEV / FVC 比值没有降低。
在本研究队列中，严重牙周炎与 FEV / FVC 比值降低和气流阻塞相关。需要进行更多的大规模前瞻性研究和干预研究以进行全面评估。
