Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Neuropeptides. 2023 Dec;102:102387. doi: 10.1016/j.npep.2023.102387. Epub 2023 Oct 12.
Oxytocin (OXT) is a hypothalamic peptide that plays a number of roles in the body, being involved in labor and lactation, as well as cognitive-emotional processes and social behavior. In recent years, knowledge of the physiology of OXT has been repeatedly used to explore its potential role in the treatment of numerous diseases, identifying a significant role for OXT in appetite regulation, eating behavior, weight regulation, and food-related beliefs. In this review we provide an overview of publications on this topic, but due to the wealth of research, we have limited our focus to studies based on the use of intranasal OXT in psychiatric diseases, with a particular focus on the role of oxytocin in eating disorders and obesity. Accumulating evidence that OXT intranasal supplementation may provide some therapeutic benefit seems promising. In individuals with autistic spectrum disorders (ASD) and schizophrenia, OXT may affect core deficits, improving social cognition and reducing symptom severity in schizophrenia. Dysregulation of serum and CSF OXT levels, as well as polymorphisms of its genes, may affect emotion perception in patients with eating disorders and correlate with co-occurring depressive and anxiety disorders. Nevertheless, there are still many critical questions regarding the pharmacokinetics and pharmacodynamics of intranasal OXT that can only be answered in larger randomized controlled trials.
催产素（OXT）是一种下丘脑肽，在体内发挥多种作用，参与分娩和哺乳，以及认知情感过程和社会行为。近年来，对 OXT 生理学的了解反复被用于探索其在治疗多种疾病中的潜在作用，确定 OXT 在食欲调节、进食行为、体重调节和与食物相关的信念中具有重要作用。在这篇综述中，我们提供了关于该主题的出版物概述，但由于研究丰富，我们将重点仅限于基于鼻内使用 OXT 的精神病学疾病的研究，特别关注 OXT 在饮食失调和肥胖症中的作用。越来越多的证据表明，鼻内补充 OXT 可能提供一些治疗益处，这似乎很有希望。在自闭症谱系障碍（ASD）和精神分裂症患者中，OXT 可能会影响核心缺陷，改善社会认知并减轻精神分裂症的症状严重程度。血清和 CSF OXT 水平的失调以及其基因的多态性可能会影响饮食失调患者的情绪感知，并与并存的抑郁和焦虑障碍相关。然而，关于鼻内 OXT 的药代动力学和药效动力学仍有许多关键问题，只能在更大的随机对照试验中得到解答。
