催产素对精神分裂症患者情绪识别的影响：一项随机双盲先导研究。
Effects of Oxytocin on Emotion Recognition in Schizophrenia: A Randomized Double-Blind Pilot Study.
机构信息
From the Department of Psychiatry, College of Medicine and Life Sciences, University of Toledo, Toledo, OH.
Atlanta Veterans Affairs Health Care System, Decatur.
出版信息
J Clin Psychopharmacol. 2021;41(2):103-113. doi: 10.1097/JCP.0000000000001367.
BACKGROUND
Schizophrenia (SCZ) is a neurodevelopmental disorder that leads to poor social function. Oxytocin (OXT), a neuropeptide involved in social cognition, is a potential therapeutic agent for alleviating social dysfunction. Therefore, we investigated the effects of intranasal oxytocin (IN-OXT) on emotional processes in experimental interactive social contexts in individuals with SCZ.
METHODS
In a male-only parallel randomized placebo-controlled double-blind trial, we investigated the effects of IN-OXT (24 IU) on visual fixation on pictures of faces and emotion recognition in an interactive ball-tossing game that probed processing of social and nonsocial stimuli.
RESULTS
Intranasal oxytocin enhanced the recognition of emotions during an emotion-based ball-tossing game. This improvement was specific to the game that included social cue processing. Intranasal oxytocin did not affect eye gaze duration or gaze dwell time on faces in these patients.
CONCLUSIONS
An acute low dose of IN-OXT had a modest effect on social cue processing and was limited to emotion recognition. Higher doses and long-term trials targeting emotional processing in SCZ may lead to improved social function.
背景
精神分裂症（SCZ）是一种导致社交功能障碍的神经发育障碍。催产素（OXT）是一种参与社交认知的神经肽，是一种缓解社交功能障碍的潜在治疗药物。因此，我们研究了鼻内给予催产素（IN-OXT）对精神分裂症患者在实验性互动社交情境中情绪过程的影响。
方法
在一项仅男性参与的平行随机安慰剂对照双盲试验中，我们研究了 IN-OXT（24IU）对面孔图片视觉注视和互动抛球游戏中情绪识别的影响，该游戏探测社交和非社交刺激的处理。
结果
鼻内催产素增强了基于情绪的抛球游戏中的情绪识别。这种改善是特定于包括社会线索处理的游戏。鼻内催产素对视场持续时间或这些患者面孔上的注视停留时间没有影响。
结论
急性低剂量 IN-OXT 对社会线索处理有适度影响，仅限于情绪识别。针对精神分裂症中情绪处理的更高剂量和长期试验可能会导致社交功能改善。
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