用土拨鼠肝炎病毒表面抗原免疫保护黑猩猩免受B型肝炎病毒感染。
Protection of chimpanzees from type B hepatitis by immunization with woodchuck hepatitis virus surface antigen.
作者信息
Cote P J, Shapiro M, Engle R E, Popper H, Purcell R H, Gerin J L
出版信息
J Virol. 1986 Dec;60(3):895-901. doi: 10.1128/JVI.60.3.895-901.1986.
Abstract
Two chimpanzees immunized with woodchuck hepatitis virus (WHV) surface antigen (WHsAg) developed antibodies cross-reactive with hepatitis B virus (HBV) surface antigen (HBsAg). After challenge with HBV, one animal was completely protected and the other experienced a subclinical infection, without evidence of liver disease. Three woodchucks immunized with HBsAg developed antibodies to HBsAg which did not cross-react with WHsAg. After challenge with WHV, all three woodchucks developed typical acute infections with associated hepatic lesions. Serological studies with the cross-reactive antibodies raised in chimpanzees suggested that the protective epitopes of WHsAg were related to the group a specificity of HBsAg. These studies indicated that cross-protective epitopes are shared by HBV and WHV; however, the humoral response to these epitopes can vary among species.
摘要
两只用土拨鼠肝炎病毒（WHV）表面抗原（WHsAg）免疫的黑猩猩产生了与乙型肝炎病毒（HBV）表面抗原（HBsAg）交叉反应的抗体。用HBV攻击后，一只动物得到完全保护，另一只经历了亚临床感染，没有肝病迹象。三只用HBsAg免疫的土拨鼠产生了与WHsAg不交叉反应的抗HBsAg抗体。用WHV攻击后，所有三只土拨鼠都出现了伴有相关肝脏病变的典型急性感染。对黑猩猩体内产生的交叉反应抗体进行的血清学研究表明，WHsAg的保护性表位与HBsAg的a组特异性有关。这些研究表明，HBV和WHV共享交叉保护表位；然而，不同物种对这些表位的体液反应可能有所不同。
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