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1
Protection of chimpanzees from type B hepatitis by immunization with woodchuck hepatitis virus surface antigen.用土拨鼠肝炎病毒表面抗原免疫保护黑猩猩免受B型肝炎病毒感染。
J Virol. 1986 Dec;60(3):895-901. doi: 10.1128/JVI.60.3.895-901.1986.
2
Woodchuck hepatitis virus: experimental infection and natural occurrence.土拨鼠肝炎病毒：实验性感染与自然发生情况
Hepatology. 1984 Sep-Oct;4(5):817-23. doi: 10.1002/hep.1840040503.
3
Immunization of woodchucks with plasmids expressing woodchuck hepatitis virus (WHV) core antigen and surface antigen suppresses WHV infection.用表达土拨鼠肝炎病毒（WHV）核心抗原和表面抗原的质粒对土拨鼠进行免疫接种可抑制WHV感染。
J Virol. 1999 Jan;73(1):281-9. doi: 10.1128/JVI.73.1.281-289.1999.
4
Surface antigenic determinants of mammalian "hepadnaviruses" defined by group- and class-specific monoclonal antibodies.由组特异性和类特异性单克隆抗体所界定的哺乳动物“嗜肝DNA病毒”的表面抗原决定簇。
J Virol. 1982 Apr;42(1):135-42. doi: 10.1128/JVI.42.1.135-142.1982.
5
Induction of antibodies to the PreS region of surface antigens of woodchuck hepatitis virus (WHV) in chronic carrier woodchucks by immunizations with WHV surface antigens.通过用土拨鼠肝炎病毒（WHV）表面抗原免疫慢性携带土拨鼠，诱导其产生针对土拨鼠肝炎病毒表面抗原前S区域的抗体。
J Hepatol. 2003 Sep;39(3):405-13. doi: 10.1016/s0168-8278(03)00241-1.
6
Experimental infection of the woodchuck (Marmota monax monax) with woodchuck hepatitis virus.用土拨鼠肝炎病毒对土拨鼠（Marmota monax monax）进行实验性感染。
Lab Invest. 1986 Jul;55(1):51-5.
7
Immunization with recombinant woodchuck hepatitis virus nucleocapsid antigen or hepatitis B virus nucleocapsid antigen protects woodchucks from woodchuck hepatitis virus infection.用重组土拨鼠肝炎病毒核衣壳抗原或乙型肝炎病毒核衣壳抗原进行免疫可保护土拨鼠免受土拨鼠肝炎病毒感染。
Vaccine. 1993;11(6):624-8. doi: 10.1016/0264-410x(93)90307-j.
8
Antigenic and structural relationships of the surface antigens of hepatitis B virus, ground squirrel hepatitis virus, and woodchuck hepatitis virus.乙型肝炎病毒、地松鼠肝炎病毒和土拨鼠肝炎病毒表面抗原的抗原性关系及结构关系。
J Virol. 1981 Aug;39(2):447-54. doi: 10.1128/JVI.39.2.447-454.1981.
9
Natural and experimental infection of woodchucks with woodchuck hepatitis virus, as measured by new, specific assays for woodchuck surface antigen and antibody.通过针对土拨鼠表面抗原和抗体的新型特异性检测方法测定，土拨鼠感染土拨鼠肝炎病毒的自然感染和实验感染情况。
J Clin Microbiol. 1982 Mar;15(3):484-90. doi: 10.1128/jcm.15.3.484-490.1982.
10
Use of the cross-reactivity with hepatitis B virus antigens and antibodies for the demonstration of a woodchuck hepatitis virus 'e' antigen-antibody system.利用与乙型肝炎病毒抗原和抗体的交叉反应性来证实土拨鼠肝炎病毒“e”抗原-抗体系统。
J Virol Methods. 1983 Jul;7(1):45-55. doi: 10.1016/0166-0934(83)90022-8.

引用本文的文献

1
DNA prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model.DNA 初免-腺病毒加强免疫可诱导小鼠和土拨鼠模型中针对嗜肝病毒蛋白的强烈和多功能 T 细胞应答。
J Virol. 2012 Sep;86(17):9297-310. doi: 10.1128/JVI.00506-12. Epub 2012 Jun 20.
2
The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection.土拨鼠作为慢性乙型肝炎病毒感染发病机制和治疗的动物模型。
World J Gastroenterol. 2007 Jan 7;13(1):104-24. doi: 10.3748/wjg.v13.i1.104.
3
Immunization with the gene expressing woodchuck hepatitis virus nucleocapsid protein fused to cytotoxic-T-lymphocyte-associated antigen 4 leads to enhanced specific immune responses in mice and woodchucks.用表达与细胞毒性T淋巴细胞相关抗原4融合的土拨鼠肝炎病毒核衣壳蛋白的基因进行免疫，可增强小鼠和土拨鼠的特异性免疫反应。
J Virol. 2005 May;79(10):6368-76. doi: 10.1128/JVI.79.10.6368-6376.2005.
4
Deficiencies in the acute-phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculation.新生儿接种后，针对病毒抗原的急性期细胞介导免疫反应缺陷与慢性土拨鼠肝炎病毒感染的发生有关。
J Virol. 2002 Feb;76(4):1769-80. doi: 10.1128/jvi.76.4.1769-1780.2002.
5
Protection against woodchuck hepatitis virus (WHV) infection by gene gun coimmunization with WHV core and interleukin-12.通过基因枪将土拨鼠肝炎病毒（WHV）核心蛋白与白细胞介素-12共同免疫来预防土拨鼠肝炎病毒感染。
J Virol. 2001 Oct;75(19):9068-76. doi: 10.1128/JVI.75.19.9068-9076.2001.
6
Immunization of woodchucks with plasmids expressing woodchuck hepatitis virus (WHV) core antigen and surface antigen suppresses WHV infection.用表达土拨鼠肝炎病毒（WHV）核心抗原和表面抗原的质粒对土拨鼠进行免疫接种可抑制WHV感染。
J Virol. 1999 Jan;73(1):281-9. doi: 10.1128/JVI.73.1.281-289.1999.
7
Natural history of experimental woodchuck hepatitis virus infection: molecular virologic features of the pancreas, kidney, ovary, and testis.实验性土拨鼠肝炎病毒感染的自然史：胰腺、肾脏、卵巢和睾丸的分子病毒学特征
J Virol. 1990 Sep;64(9):4499-506. doi: 10.1128/JVI.64.9.4499-4506.1990.
8
Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host.在共同宿主中，土拨鼠肝炎病毒比地松鼠肝炎病毒是一种更有效的致癌因子。
J Virol. 1991 Apr;65(4):1673-9. doi: 10.1128/JVI.65.4.1673-1679.1991.

本文引用的文献

1
Animal model of human disease. Chimpanzee carriers of hepatitis B virus. Chimpanzee hepatitis B carriers.人类疾病动物模型。乙型肝炎病毒的黑猩猩携带者。黑猩猩乙型肝炎携带者。
Am J Pathol. 1981 Dec;105(3):328-32.
2
Three recently described animal virus models for human hepatitis B virus.最近描述的三种用于人类乙型肝炎病毒的动物病毒模型。
Hepatology. 1981 Mar-Apr;1(2):179-83. doi: 10.1002/hep.1840010215.
3
Nucleotide sequence of a cloned woodchuck hepatitis virus genome: comparison with the hepatitis B virus sequence.克隆的土拨鼠肝炎病毒基因组的核苷酸序列：与乙肝病毒序列的比较。
J Virol. 1982 Jan;41(1):51-65. doi: 10.1128/JVI.41.1.51-65.1982.
4
Natural and experimental infection of woodchucks with woodchuck hepatitis virus, as measured by new, specific assays for woodchuck surface antigen and antibody.通过针对土拨鼠表面抗原和抗体的新型特异性检测方法测定，土拨鼠感染土拨鼠肝炎病毒的自然感染和实验感染情况。
J Clin Microbiol. 1982 Mar;15(3):484-90. doi: 10.1128/jcm.15.3.484-490.1982.
5
Genetic variation among hepatitis B and related viruses.乙型肝炎及相关病毒的基因变异
Ann N Y Acad Sci. 1980;354:371-8. doi: 10.1111/j.1749-6632.1980.tb27978.x.
6
Type B hepatitis: a review of current prospects for a safe and effective vaccine.乙型肝炎：安全有效疫苗当前前景综述
Rev Infect Dis. 1980 May-Jun;2(3):470-92. doi: 10.1093/clinids/2.3.470.
7
Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States.乙肝疫苗：在美国高危人群的对照临床试验中疗效的证明
N Engl J Med. 1980 Oct 9;303(15):833-41. doi: 10.1056/NEJM198010093031501.
8
Nonoverlapping antigenic sites of woodchuck hepatitis virus surface antigen and their cross-reactivity with ground squirrel hepatitis virus and hepatitis B virus surface antigens.土拨鼠肝炎病毒表面抗原的非重叠抗原位点及其与地松鼠肝炎病毒和乙型肝炎病毒表面抗原的交叉反应性。
J Virol. 1983 Jul;47(1):15-23. doi: 10.1128/JVI.47.1.15-23.1983.
9
Structural relationships between minor and major proteins of hepatitis B surface antigen.乙型肝炎表面抗原次要蛋白与主要蛋白之间的结构关系。
J Virol. 1983 May;46(2):626-8. doi: 10.1128/JVI.46.2.626-628.1983.
10
Antigenic cross-reactions between woodchuck hepatitis virus and human hepatitis B virus shown by immune electron microscopy.通过免疫电子显微镜观察显示土拨鼠肝炎病毒与人类乙型肝炎病毒之间的抗原交叉反应。
J Gen Virol. 1983 Apr;64 (Pt 4):975-80. doi: 10.1099/0022-1317-64-4-975.

用土拨鼠肝炎病毒表面抗原免疫保护黑猩猩免受B型肝炎病毒感染。

Protection of chimpanzees from type B hepatitis by immunization with woodchuck hepatitis virus surface antigen.

作者信息

Cote P J, Shapiro M, Engle R E, Popper H, Purcell R H, Gerin J L

出版信息

J Virol. 1986 Dec;60(3):895-901. doi: 10.1128/JVI.60.3.895-901.1986.

DOI:10.1128/JVI.60.3.895-901.1986
PMID:3783820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC253316/
Abstract

Two chimpanzees immunized with woodchuck hepatitis virus (WHV) surface antigen (WHsAg) developed antibodies cross-reactive with hepatitis B virus (HBV) surface antigen (HBsAg). After challenge with HBV, one animal was completely protected and the other experienced a subclinical infection, without evidence of liver disease. Three woodchucks immunized with HBsAg developed antibodies to HBsAg which did not cross-react with WHsAg. After challenge with WHV, all three woodchucks developed typical acute infections with associated hepatic lesions. Serological studies with the cross-reactive antibodies raised in chimpanzees suggested that the protective epitopes of WHsAg were related to the group a specificity of HBsAg. These studies indicated that cross-protective epitopes are shared by HBV and WHV; however, the humoral response to these epitopes can vary among species.

摘要

两只用土拨鼠肝炎病毒（WHV）表面抗原（WHsAg）免疫的黑猩猩产生了与乙型肝炎病毒（HBV）表面抗原（HBsAg）交叉反应的抗体。用HBV攻击后，一只动物得到完全保护，另一只经历了亚临床感染，没有肝病迹象。三只用HBsAg免疫的土拨鼠产生了与WHsAg不交叉反应的抗HBsAg抗体。用WHV攻击后，所有三只土拨鼠都出现了伴有相关肝脏病变的典型急性感染。对黑猩猩体内产生的交叉反应抗体进行的血清学研究表明，WHsAg的保护性表位与HBsAg的a组特异性有关。这些研究表明，HBV和WHV共享交叉保护表位；然而，不同物种对这些表位的体液反应可能有所不同。