土拨鼠肝炎病毒表面抗原的非重叠抗原位点及其与地松鼠肝炎病毒和乙型肝炎病毒表面抗原的交叉反应性。
Nonoverlapping antigenic sites of woodchuck hepatitis virus surface antigen and their cross-reactivity with ground squirrel hepatitis virus and hepatitis B virus surface antigens.
作者信息
Cote P J, Gerin J L
出版信息
J Virol. 1983 Jul;47(1):15-23. doi: 10.1128/JVI.47.1.15-23.1983.
Abstract
Five nonoverlapping antigenic sites (sites I through V) of woodchuck hepatitis virus surface antigen were identified with competitive binding assays involving monoclonal antibodies. Site I contributed to cross-reactions among surface antigens of hepatitis B-like viruses infecting woodchucks, ground squirrels, and humans. At least three distinct sites (sites I, II, and III) are responsible for cross-reactions between woodchuck and ground squirrel hepatitis virus surface antigens. Sites IV and V of woodchuck hepatitis virus surface antigen are not major cross-reactive sites, suggesting that these elicit virus-specific antibodies. There were no cross-reactions with duck hepatitis B virus surface antigen.
摘要
利用涉及单克隆抗体的竞争性结合试验，鉴定出了土拨鼠肝炎病毒表面抗原的五个不重叠的抗原位点（位点I至V）。位点I导致感染土拨鼠、地松鼠和人类的乙型肝炎样病毒表面抗原之间发生交叉反应。至少三个不同的位点（位点I、II和III）导致土拨鼠和地松鼠肝炎病毒表面抗原之间发生交叉反应。土拨鼠肝炎病毒表面抗原的位点IV和V不是主要的交叉反应位点，这表明这些位点引发病毒特异性抗体。与鸭乙型肝炎病毒表面抗原没有交叉反应。
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