Danish Center for Mindfulness, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Denmark.
BMC Complement Med Ther. 2023 Oct 14;23(1):364. doi: 10.1186/s12906-023-04194-3.
Stress and mental disorders in pregnancy can adversely affect the developing fetus. Women with a preconception history of mental disorders or of psychosocial vulnerabilities are at increased risk of experiencing perinatal stress or mental health problems. Mindfulness-Based-Stress-Reduction (MBSR) is an acceptable intervention for pregnant women and has a growing evidence-base with meta-analyses consistently pointing to reductions in symptoms of stress, anxiety and depression. This study protocol aim to address the need for a wider array of evidence-based and non-pharmacological options during pregnancy to reduce stress and improve mental health in a psychosocially highly vulnerable group of women.
Pregnant women with a preconception history of mental disorders or psychosocial vulnerabilities (n = 240) will be recruited from an obstetric ambulatory clinic at Copenhagen University Hospital, Hvidovre, Denmark. Recruitment for the study began in March 2022 and will continue until the desired number of participants is reached. Consenting pregnant women will be randomized to one of two study arms, an adapted MBSR program as add on to usual care or usual care alone. The primary outcome is mental wellbeing at nine months post-randomization. Secondary and exploratory outcomes include stress, anxiety, depression, and maternal antenatal attachment, experience of childbirth, delivery and mode of delivery. Mindfulness and self-compassion are examined as possible mediators of the effect on outcomes.
Teaching the skills of mindfulness meditation to a psychosocially vulnerable group of pregnant women could prove a viable and non-pharmacological approach to improve mental health and wellbeing during pregnancy, reduce stress and support the transition to parenthood. Mindfulness-Based Stress Reduction does not target a particular group, and results from the study is thus of potential relevance for pregnant women in general as a means of reducing stress and improving perinatal mental health and wellbeing.
ClinicalTrials.gov: NCT05300646 . Registered March 29, 2022.
孕期的压力和精神障碍会对胎儿的发育产生不利影响。有精神障碍或心理社会脆弱性孕前史的女性，在经历围产期压力或精神健康问题方面的风险增加。基于正念的减压（MBSR）是一种可以接受的孕妇干预措施，并且具有越来越多的证据基础，荟萃分析一致指出，它可以减轻压力、焦虑和抑郁症状。本研究方案旨在满足在围产期提供更广泛的基于证据和非药物选择的需求，以减轻压力和改善心理社会高度脆弱群体女性的心理健康。
将从丹麦哥本哈根大学医院 Hvidovre 产科门诊招募有精神障碍或心理社会脆弱性孕前史的孕妇（n=240）。该研究于 2022 年 3 月开始招募，将继续招募，直到达到预期的参与者数量。同意参加的孕妇将被随机分配到两个研究组之一，即附加常规护理的改编版 MBSR 方案或单独常规护理。主要结局是随机分组后九个月的心理健康状况。次要和探索性结局包括压力、焦虑、抑郁和产妇产前依恋、分娩经历、分娩方式。正念和自我同情被视为对结局影响的可能中介因素。
向心理社会脆弱的孕妇群体教授正念冥想技能可能是一种可行的非药物方法，可以改善孕期的心理健康和幸福感，减轻压力，支持向父母身份的过渡。基于正念的减压并不针对特定群体，因此研究结果对一般孕妇具有潜在相关性，是减轻压力和改善围产期心理健康和幸福感的一种手段。
ClinicalTrials.gov：NCT05300646。2022 年 3 月 29 日注册。
