软骨寡聚基质蛋白过表达是肝内胆管细胞癌患者的独立不良预后指标。
Cartilage oligomeric matrix protein overexpression is an independent poor prognostic indicator in patients with intrahepatic cholangiocarcinoma.
机构信息
Division of Gastroenterology and General Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, 710, Taiwan, ROC.
Department of Medical Technology, Chung Hwa University of Medical Technology, Tainan, 717, Taiwan, ROC.
出版信息
Sci Rep. 2023 Oct 14;13(1):17444. doi: 10.1038/s41598-023-43006-z.
Cartilage oligomeric matrix protein (COMP) interacts with various extracellular matrix proteins in tissues. Elevated COMP levels recently linked to worse overall survival in multiple cancer types. COMP's significance in intrahepatic cholangiocarcinoma (iCCA) remains uncertain. Here we report a retrospective study to explore COMP's impact on iCCA outcomes. We collected 182 patients' iCCA tumor tissues. COMP overexpression was associated with adverse factors like R1 resection (p = 0.008), advanced T stage (p < 0.001), large duct type (p = 0.004), and poorly differentiated histology (p = 0.002). COMP overexpression correlates with poorer DFS (HR, 3.651; p = 0.001), OS (HR, 1.827; p = 0.023), LRFS (HR, 4.077; p < 0.001), and MFS (HR, 3.718; p < 0.001). High COMP expression ties to worse overall survival (p = 0.0001), DSS (p < 0.0001), LRFS (p < 0.0001), and MFS (p < 0.0001). In conclusion, COMP overexpression links to poor prognosis and pathological features in iCCA, indicating its potential as a biomarker.
软骨寡聚基质蛋白 (COMP) 与组织中的各种细胞外基质蛋白相互作用。最近，COMP 水平升高与多种癌症类型的总生存率降低有关。COMP 在肝内胆管癌 (iCCA) 中的意义仍不确定。在这里，我们报告了一项回顾性研究，以探讨 COMP 对 iCCA 结局的影响。我们收集了 182 名患者的 iCCA 肿瘤组织。COMP 过表达与不良因素相关，如 R1 切除（p=0.008）、晚期 T 分期（p<0.001）、大导管型（p=0.004）和低分化组织学（p=0.002）。COMP 过表达与较差的DFS（HR，3.651；p=0.001）、OS（HR，1.827；p=0.023）、LRFS（HR，4.077；p<0.001）和 MFS（HR，3.718；p<0.001）相关。高 COMP 表达与总体生存率降低（p=0.0001）、DSS（p<0.0001）、LRFS（p<0.0001）和 MFS（p<0.0001）相关。总之，COMP 过表达与 iCCA 的不良预后和病理特征相关，表明其作为生物标志物的潜力。
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