College of Chemistry and Materials Science, Jinan University, Guangzhou 511443, China; Engineering Research Center of Artificial Organs and Materials, Ministry of Education, Guangzhou 510632, China.
Department of Orthopaedics, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou 510630, China.
Int J Biol Macromol. 2023 Dec 31;253(Pt 7):127441. doi: 10.1016/j.ijbiomac.2023.127441. Epub 2023 Oct 14.
Sports-related damage is a prevalent issue, which a combination therapy including photothermal irradiation, self-healing dressing and antibacterial treatment is an effective way to rehabilitate it. In the study, a multifunctional hydrogel was developed to meet the requirement. Firstly, mesoporous polydopamine (MPDA) was prepared, where gold nanoparticles (Au NPs) were formed in its mesoporous structure, to construct Au@MPDA NPs with nanosize about 200 nm. Synergetic and efficient photothermal effect was achieved by the combination of the two photothermal agents. The Au@MPDA NPs were then added to modify polyvinyl alcohol-carboxymethyl chitosan-borax (PCB) hydrogel. Via rheological property characterization, cell experiments and antibacterial evaluation, high photothermal efficiency and effective antibacterial activity of Au@MPDA@PCB hydrogel was obtained with the aid of Au@MPDA NPs, together with self-healing property. When treated in motion-related tissue, the modified hydrogel showed excellent adaptive property and photothermal effect in situ. This study is beneficial for developing a novel rehabilitation treatment strategy for sports-related injuries.
运动相关损伤是一个普遍存在的问题，包括光热辐射、自修复敷料和抗菌治疗在内的联合疗法是一种有效的康复方法。在这项研究中，开发了一种多功能水凝胶来满足这一需求。首先，制备了介孔聚多巴胺（MPDA），其中在其介孔结构中形成了金纳米粒子（Au NPs），以构建具有约 200nm 纳米尺寸的 Au@MPDA NPs。两种光热剂的结合实现了协同高效的光热效应。然后将 Au@MPDA NPs 添加到改性聚乙烯醇-羧甲基壳聚糖-硼砂（PCB）水凝胶中。通过流变性能表征、细胞实验和抗菌评价，在 Au@MPDA NPs 的辅助下，获得了具有自修复性能的 Au@MPDA@PCB 水凝胶的高光热效率和有效抗菌活性。当在与运动相关的组织中进行处理时，改性水凝胶在原位表现出优异的适应性和光热效应。这项研究有助于开发一种用于运动相关损伤的新型康复治疗策略。
