Zhang Wei, Li Xinyi, Chen Wenjian, Huang Xiaoyi, Hua Tianfeng, Hu Jinpeng, Zhu Jing, Ye Sheng, Li Xiaojing
Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University Hefei 230022 Anhui China.
Department of Orthopaedics, Anhui Provincial Children's Hospital Hefei Anhui 230022 China.
RSC Adv. 2024 Jun 7;14(26):18317-18329. doi: 10.1039/d4ra00135d. eCollection 2024 Jun 6.
Wound management remains a challenge in clinical practice. Nowadays, patients have an increasing demand for wound repair with enhanced speed and quality; therefore, there is a great need to seek therapeutic strategies that can promote rapid and effective wound healing. In this study, we developed a carboxymethyl cellulose hydrogel loaded with l-carnosine (CRN@hydrogel) for potential application as a wound dressing. experiments confirmed that CRN@hydrogel can release over 80% of the drug within 48 h and demonstrated its favorable cytocompatibility and blood compatibility, thus establishing its applicability for safe utilization in clinical practice. Using a rat model, we found that this hydrogel could promote and accelerate wound healing more effectively. These results indicate that the novel hydrogel can serve as an efficient therapeutic strategy for wound treatment.
伤口管理在临床实践中仍然是一项挑战。如今，患者对伤口修复的速度和质量要求越来越高；因此，迫切需要寻找能够促进伤口快速有效愈合的治疗策略。在本研究中，我们开发了一种负载L-肌肽的羧甲基纤维素水凝胶（CRN@水凝胶），有望作为伤口敷料应用。实验证实，CRN@水凝胶在48小时内可释放超过80%的药物，并证明其具有良好的细胞相容性和血液相容性，从而确定了其在临床实践中安全应用的适用性。使用大鼠模型，我们发现这种水凝胶可以更有效地促进和加速伤口愈合。这些结果表明，这种新型水凝胶可作为一种有效的伤口治疗策略。
