Department of Pulmonary, Critical Care and Sleep Medicine, McGovern School of Medicine, University of Texas McGovern Medical School, Houston, TX, USA.
Department of Pulmonary, Critical Care and Sleep Medicine, McGovern School of Medicine, University of Texas McGovern Medical School, Houston, TX, USA.
Respir Med. 2023 Nov-Dec;219:107426. doi: 10.1016/j.rmed.2023.107426. Epub 2023 Oct 13.
Amyloidosis is caused by abnormal protein deposition in various tissues, including the lungs. Pulmonary manifestations of amyloidosis may be categorized by areas of involvement, such as parenchymal, large airway and pleural involvement. We describe four distinct manifestations of amyloidosis involving the lung and review their clinical, radiological and pathological features and summarize the evidence for treatment in each of these presentations. We describe alveolar-septal amyloidosis, cystic amyloid lung disease, endobronchial amyloidosis and pleural amyloidosis.
淀粉样变性是由各种组织中异常蛋白质沉积引起的，包括肺部。淀粉样变性的肺部表现可根据受累部位进行分类，例如实质、大气道和胸膜受累。我们描述了涉及肺部的淀粉样变性的四种不同表现，并回顾了它们的临床、放射学和病理学特征，并总结了这些表现中每种表现的治疗证据。我们描述了肺泡-间隔淀粉样变性、囊性淀粉样肺疾病、支气管内淀粉样变性和胸膜淀粉样变性。
