Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada; Rotman Research Institute, Baycrest Health Sciences, Toronto, ON M6A 2E1, Canada; Music and Health Research Collaboratory, Faculty of Music, University of Toronto, Toronto, ON M5S 2C5, Canada.
Department of Psychology, York University, Toronto, ON M3J 1P3, Canada.
Neurosci Biobehav Rev. 2023 Nov;154:105423. doi: 10.1016/j.neubiorev.2023.105423. Epub 2023 Oct 13.
Accumulating evidence suggests that the neural activations during music listening differs as a function of familiarity with the excerpts. However, the implicated brain areas are unclear. After an extensive literature search, we conducted an Activation Likelihood Estimation analysis on 23 neuroimaging studies (232 foci, 364 participants) to identify consistently activated brain regions when healthy adults listen to familiar music, compared to unfamiliar music or an equivalent condition. The results revealed a left cortical-subcortical co-activation pattern comprising three significant clusters localized to the supplementary motor areas (BA 6), inferior frontal gyrus (IFG, BA 44), and the claustrum/insula. Our results are discussed in a predictive coding framework, whereby temporal expectancies and familiarity may drive motor activations, despite any overt movement. Though conventionally associated with syntactic violation, our observed activation in the IFG may support a recent proposal of its involvement in a network that subserves both violation and prediction. Finally, the claustrum/insula plays an integral role in auditory processing, functioning as a hub that integrates sensory and limbic information to (sub)cortical structures.
越来越多的证据表明，人们在听音乐时的神经活动会因对音乐片段的熟悉程度而有所不同。然而，涉及的大脑区域尚不清楚。经过广泛的文献检索，我们对 23 项神经影像学研究（232 个焦点，364 名参与者）进行了激活似然估计分析，以确定当健康成年人听熟悉的音乐与听不熟悉的音乐或同等条件相比时，大脑中始终处于激活状态的区域。结果显示，左皮质-皮质下共同激活模式包括三个显著的簇，定位于辅助运动区（BA6）、下额回（IFG，BA44）和屏状核/脑岛。我们的结果在预测编码框架中进行了讨论，即时间预期和熟悉度可能会驱动运动激活，尽管没有任何明显的运动。尽管通常与语法违规有关，但我们在 IFG 中观察到的激活可能支持最近提出的其参与了一个既支持违规又支持预测的网络的观点。最后，屏状核/脑岛在听觉处理中起着至关重要的作用，作为一个整合感觉和边缘信息的枢纽，将其传递给（皮质下）结构。
