Center for Food and Bioconvergence, Seoul National University, Gwanakgu, Seoul 08826, Republic of Korea.
Binggrae Co. Ltd., Namyangjusi, Gyeonggido 12253, Republic of Korea.
Carbohydr Polym. 2023 Dec 15;322:121341. doi: 10.1016/j.carbpol.2023.121341. Epub 2023 Aug 29.
Emulgels are a type of soft solid delivery system that exploit the merits of both emulsions and gels, namely, bioactive encapsulability and structural stability, respectively. We utilized retrograded/octenylsuccinylated maize starch (ROMS) to fabricate the curcumin-loaded emulgel. Emulgels (oil volume fraction, 0.20) prepared with 1-4 % w/w ROMS exhibited fluid-like behaviors while emulgels with 5-8 % w/w ROMS exhibited a gel-like consistency. Compared to a fluidic emulsion stabilized with 3 % w/w octenylsuccinylated maize starch, the emulgels showed more sustained lipolysis and controlled curcumin release patterns. These results were attributed to rigid ROMS structures at the outer layer of oil droplets, hindering the lipase approach onto the oil/water interface and curcumin diffusion from the interface. Additionally, the bioaccessibility of curcumin in ROMS-stabilized emulgels was enhanced >9.6-fold compared to that of a curcumin solution. Furthermore, emulgels prepared with 8 % w/w ROMS exhibited a high yield stress (376.4 Pa) and maintained appearance and droplet size for 60 days of storage at 4 °C. Consequently, this emulgel has potential as a lipophilic bioactive-containing soft gel with sustained digestion and controlled release properties. Our findings may provide insights into rational delivery system designs.
Emulgels 是一种软固体制剂，兼具乳液和凝胶的优点，分别为生物活性包封性和结构稳定性。我们利用回生/辛烯基琥珀酸化玉米淀粉（ROMS）制备姜黄素负载型乳凝胶。油体积分数为 0.20 的含有 1-4%w/w ROMS 的乳凝胶表现出类似流体的行为，而含有 5-8%w/w ROMS 的乳凝胶则表现出凝胶状的稠度。与由 3%w/w 辛烯基琥珀酸化玉米淀粉稳定的流体乳液相比，乳凝胶表现出更持久的脂肪酶水解和更受控的姜黄素释放模式。这归因于油滴外层的刚性 ROMS 结构，阻碍了脂肪酶接近油/水界面和姜黄素从界面扩散。此外，与姜黄素溶液相比，ROMS 稳定的乳凝胶中姜黄素的生物利用度提高了>9.6 倍。此外，含有 8%w/w ROMS 的乳凝胶表现出高屈服应力（376.4 Pa），并在 4°C 下储存 60 天保持外观和液滴大小。因此，这种乳凝胶具有作为具有持续消化和控制释放特性的亲脂性含生物活性软凝胶的潜力。我们的研究结果可能为合理的给药系统设计提供思路。
